DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD04855
Drug Name	Dronedarone
Molecular Weight	556.756
Molecular Formula	C31H44N2O5S
CAS Number	141626-36-0
SMILES	CCCCN(CCCC)CCCOC1=CC=C(C=C1)C(=O)C1=C(CCCC)OC2=C1C=C(NS(C)(=O)=O)C=C2
External Links
	DRUGBANK	DB04855
	PubChem Compound	208898
	PDR	522
	Drugs.com	Drugs.com Drug Page

Experimental Physicochemical Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Log P	4.63	-	4.63	-	MULTAQ? (dronedarone) Safety Data Sheet - Van Wert Health
Melting Point	141.0	℃	137-145	℃	MULTAQ? (dronedarone) Safety Data Sheet - Van Wert Health
Water Solubility	640.0	mg/L	0.64	g/l	MULTAQ? dronedarone) Safety Data Sheet - Van Wert Health

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Reference
Absorption	70.0	%	>70	%	PO, oral;	DRUGBANK
Bioavailability	4.0	%	4	%	PO, oral;	DRUGBANK
Bioavailability	15.0	%	15	%	PO, oral; high-fat meal;	DRUGBANK
T Max	4.5	h	3-6	h	PO, oral; Active metabolite;	DRUGBANK
Tss	144.0	h	4-8	day	Oral multiple dose;	DRUGBANK
Clearance	140.0	L/h	130-150	L/h	intravenous injection, IV;	DRUGBANK
Clearance	2.0	L/h/kg	33.33	ml/min/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Volume of Distribution	1300.0	L	1200-1400	L	at steady state; intravenous injection, IV;	DRUGBANK
Volume of Distribution	20.0	L/kg	20	L/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Half-life	16.0	h	13-19	h	elimination half-life;	DRUGBANK
Half-life	16.0	h	16	h	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Toxicity LD50	2000.0	mg/kg	>2000	mg/kg	PO, oral; Rattus, Rat;	DRUGBANK
Eliminate Route	84.0	%	~84	%	Faeces excretion; PO, oral;	DRUGBANK
Eliminate Route	6.0	%	6	%	Urinary excretion; PO, oral;	DRUGBANK
Protein Binding	99.7	%	99.7	%	plasma proteins; high protein binding;	DRUGBANK

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for adults	800.0	mg/day	800	mg/day	PO, oral	Multaq	dronedarone	PDR
Max dose for geriatric	800.0	mg/day	800	mg/day	PO, oral	Multaq	dronedarone	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1