Basic Information
| Drug ID | DDPD04854 |
|
| Drug Name | Febuxostat | |
| Molecular Weight | 316.375 | |
| Molecular Formula | C16H16N2O3S | |
| CAS Number | 144060-53-7 | |
| SMILES | CC(C)COC1=C(C=C(C=C1)C1=NC(C)=C(S1)C(O)=O)C#N | |
| External Links | ||
| DRUGBANK | DB04854 | |
| PubChem Compound | 134018 | |
| PDR | 24361 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Melting Point | 238.0 | ℃ | 238-239 | ℃ | Patent WO2012056442 A1 |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 49.0 | % | >49 | % | DRUGBANK | |
| Metabolic | 35.0 | % | 35 | % | DRUGBANK | Metabolic | 10.0 | % | 10 | % | DRUGBANK | Metabolic | 11.0 | % | 11 | % | DRUGBANK | Metabolic | 14.0 | % | 14 | % | DRUGBANK |
| Volume of Distribution | 50.0 | L | 50.0 | L | Steady state volume of distribution; | DRUGBANK |
| Half-life | 6.5 | h | ~5-8 | h | DRUGBANK | |
| Protein Binding | 99.2 | % | 99.2 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 120.0 | mg/day | 120 | mg/day | PO, oral | Febuxostat | febuxostat | PDR |
| Max dose for geriatric | 120.0 | mg/day | 120 | mg/day | PO, oral | Febuxostat | febuxostat | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1