Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD04845 ...
Drug Name Ixabepilone
Molecular Weight 506.7
Molecular Formula C27H42N2O5S
CAS Number 219989-84-1
SMILES [H][C@]12C[C@H](NC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC[C@@]1(C)O2)C(\C)=C\C1=CSC(C)=N1
External Links
DRUGBANK DB04845
PubChem Compound 6445540
PDR 108

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Clearance 0.60 L/h/kg 10 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 11.0 L/kg 11 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 52.0 h 52 h DRUGBANK
Half-life 17.0 h 17 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Protein Binding 72.0 % 67-77 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for adults 40.0 mg/m2 40 mg/m2 intravenous injection, IV q3w Ixempra ixabepilone PDR
Max dose for adults 20.0 mg/m2 20 mg/m2 intravenous injection, IV q3w Ixempra ixabepilone PDR
Max dose for elderly 40.0 mg/m2 40 mg/m2 intravenous injection, IV q3w Ixempra ixabepilone PDR
Max dose for elderly 20.0 mg/m2 20 mg/m2 intravenous injection, IV q3w Ixempra ixabepilone PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1