Basic Information
| Drug ID | DDPD04743 |
|
| Drug Name | Nimesulide | |
| Molecular Weight | 308.31 | |
| Molecular Formula | C13H12N2O5S | |
| CAS Number | 51803-78-2 | |
| SMILES | CS(=O)(=O)NC1=C(OC2=CC=CC=C2)C=C(C=C1)[N+]([O-])=O | |
| External Links | ||
| DRUGBANK | DB04743 | |
| PubChem Compound | 4495 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.6 | - | 2.6 | - | SANGSTER (1993) |
| Melting Point | 143.75 | ℃ | 143-144.5 | ℃ | PhysProp |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Half-life | 3.3 | h | 1.8-4.7 | h | DRUGBANK | |
| Toxicity LD50 | 200.0 | mg/kg | 200.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 392.0 | mg/kg | 392.0 | mg/kg | PO, oral; mouse; | DRUGBANK |
| Toxicity TDLo | 1.4 | mg/kg | 1.429 | mg/kg | PO, oral; human, homo sapiens; | DRUGBANK | Toxicity TDLo | 2.0 | mg/kg | 2.0 | mg/kg | PO, oral; Female, women; | DRUGBANK |
| Eliminate Route | 50.0 | % | 50 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 29.0 | % | 29 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 97.5 | % | >97.5 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1