Basic Information
| Drug ID | DDPD04572 |
|
| Drug Name | Thiotepa | |
| Molecular Weight | 189.218 | |
| Molecular Formula | C6H12N3PS | |
| CAS Number | 52-24-4 | |
| SMILES | S=P(N1CC1)(N1CC1)N1CC1 | |
| External Links | ||
| DRUGBANK | DB04572 | |
| T3DB | T3D4716 | |
| PubChem Compound | 5453 | |
| PDR | 24101 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.53 | - | 0.53 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 51.5 | ℃ | 51.5 | ℃ | PhysProp |
| Water Solubility | 190000.0 | mg/L | 190000 | mg/L | MERCK INDEX 1996) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 26.8 | L/h | 446±63 | ml/min | intravenous infusion, IV in drop; ovarian cancer; patients; Female, women; | DRUGBANK | Clearance | 0.40 | L/h/kg | 6.7 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.6 | L/kg | 1.6 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 2.8 | h | 1.5-4.1 | h | DRUGBANK | Half-life | 2.7 | h | 2.7 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 63.0 | % | 63 | % | Urinary excretion; intravenous injection, IV; patients; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for infants | 5.0 | mg/kg | 5 | mg/kg | intravenous injection, IV | bid | Tepadina | thiotepa | PDR |
| Max dose for children | 5.0 | mg/kg | 5 | mg/kg | intravenous injection, IV | bid | Tepadina | thiotepa | PDR |
| Max dose for adolescents | 5.0 | mg/kg | 5 | mg/kg | intravenous injection, IV | bid | Tepadina | thiotepa | PDR |
| Max dose for adults | 0.8 | mg/kg | 0.8 | mg/kg | Intraperitoneal, IP | Tepadina | thiotepa | PDR | |
| Max dose for adults | 60.0 | mg | 60 | mg | intravesically | Tepadina | thiotepa | PDR | |
| Max dose for adults | 0.4 | mg/kg | 0.4 | mg/kg | intravenous injection, IV | Tepadina | thiotepa | PDR | |
| Max dose for geriatric | 0.8 | mg/kg | 0.8 | mg/kg | Intraperitoneal, IP | Tepadina | thiotepa | PDR | |
| Max dose for geriatric | 60.0 | mg | 60 | mg | intravesically | Tepadina | thiotepa | PDR | |
| Max dose for geriatric | 0.4 | mg/kg | 0.4 | mg/kg | intravenous injection, IV | Tepadina | thiotepa | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1