Basic Information
| Drug ID | DDPD02546 |
|
| Drug Name | Vorinostat | |
| Molecular Weight | 264.3202 | |
| Molecular Formula | C14H20N2O3 | |
| CAS Number | 149647-78-9 | |
| SMILES | ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 | |
| External Links | ||
| DRUGBANK | DB02546 | |
| PubChem Compound | 5311 | |
| PDR | 403 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| pKa | 9.2 | - | 9.2 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 1.7 | L/h/kg | 28 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.50 | L/kg | 0.5 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 0.76 | h | 0.76 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 1.0 | % | <1 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 71.0 | % | 71 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 400.0 | mg/day | 400 | mg/day | PO, oral | Zolinza | vorinostat | PDR |
| Max dose for elderly | 400.0 | mg/day | 400 | mg/day | PO, oral | Zolinza | vorinostat | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1