DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD01708
Drug Name	Prasterone
Molecular Weight	288.4244
Molecular Formula	C19H28O2
CAS Number	53-43-0
SMILES	[H][C@@]12CCC(=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@]([H])(O)CC[C@]12C
External Links
	DRUGBANK	DB01708
	PubChem Compound	5881
	PDR	24099

Experimental Physicochemical Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Log P	3.23	-	3.23	-	HANSCH,C ET AL. (1995)
Melting Point	140.5	℃	140-141	℃	PhysProp
Water Solubility	63.5	mg/L	63.5	mg/L	YALKOWSKY,SH & DANNENFELSER,RM 1992)

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Reference
Bioavailability	3.1	%	3.1±0.4	%	PO, oral; monkey;	DRUGBANK
Half-life	12.0	h	12	h		DRUGBANK
Toxicity LD50	10000.0	mg/kg	>10000	mg/kg	PO, oral; Rattus, Rat;	DRUGBANK
Toxicity TDLo	0.71	mg/kg/day	10.0	mg/kg/2W		DRUGBANK

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Frequency	Brand Name	Component	Reference
Max dose for adults	6.5	mg	6.5	mg	Vaginal Administration	qd	Intrarosa	prasterone insert	PDR
Max dose for geriatric	6.5	mg	6.5	mg	Vaginal Administration	qd	Intrarosa	prasterone insert	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1