DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD01656
Drug Name	Roflumilast
Molecular Weight	403.207
Molecular Formula	C17H14Cl2F2N2O3
CAS Number	162401-32-3
SMILES	FC(F)OC1=C(OCC2CC2)C=C(C=C1)C(=O)NC1=C(Cl)C=NC=C1Cl
External Links
	DRUGBANK	DB01656
	PubChem Compound	449193
	PDR	157
	Drugs.com	Drugs.com Drug Page

Experimental Physicochemical Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Melting Point	159.7	℃	159.7	℃	DRUGBANK
Water Solubility	0.54	mg/L	0.52-0.56	mg/L	DRUGBANK
pKa	8.74	-	8.74	-	DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Factor	Reference
Bioavailability	80.0	%	~80	%	PO, oral;		DRUGBANK
T Max	1.3	h	0.5-2	h	PO, oral; fasting;		DRUGBANK
T Max	2.3	h	1.5-3	h	PO, oral; food;	food ↑ ;	DRUGBANK
Clearance	9.6	L/h	~9.6	L/h			DRUGBANK
Clearance	0.13	L/h/kg	2.2	ml/min/kg	intravenous injection, IV; human, homo sapiens;		Human Intravenous Pharmacokinetic Dataset
Volume of Distribution	2.9	L/kg	2.9	L/kg			DRUGBANK
Volume of Distribution	1.9	L/kg	1.92	L/kg	intravenous injection, IV; human, homo sapiens;		Human Intravenous Pharmacokinetic Dataset
Half-life	17.0	h	17	h	elimination half-life; PO, oral;		DRUGBANK
Half-life	30.0	h	30	h	Metabolite;		DRUGBANK
Half-life	15.1	h	15.1	h	intravenous injection, IV; human, homo sapiens;		Human Intravenous Pharmacokinetic Dataset
Protein Binding	99.0	%	99	%	plasma proteins;		DRUGBANK

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for adults	0.5	mg/day	500	mcg/day	PO, oral	Daliresp	roflumilast	PDR
Max dose for geriatric	0.5	mg/day	500	mcg/day	PO, oral	Daliresp	roflumilast	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1