Basic Information
| Drug ID | DDPD01627 |
|
| Drug Name | Lincomycin | |
| Molecular Weight | 406.54 | |
| Molecular Formula | C18H34N2O6S | |
| CAS Number | 154-21-2 | |
| SMILES | [H][C@]1(C[C@@H](CCC)CN1C)C(=O)N[C@H]([C@@H](C)O)[C@H]1O[C@H](SC)[C@H](O)[C@@H](O)[C@H]1O | |
| External Links | ||
| DRUGBANK | DB01627 | |
| PubChem Compound | 3000540 | |
| PDR | 1878 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.56 | - | 0.56 | - | HANSCH,C ET AL. (1995) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Absorption | 25.0 | % | 20-30 | % | PO, oral; fasting; | DRUGBANK | |
| Clearance | 0.13 | L/h/kg | 2.1 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset | |
| Volume of Distribution | 1.0 | L/kg | 1 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset | |
| Half-life | 5.4 | h | 5.4±1.0 | h | elimination half-life; intravenous injection, IV; | severe renal function ↑ ; | DRUGBANK | Half-life | 5.4 | h | 5.4±1.0 | h | elimination half-life; IM,intramuscular injection; | DRUGBANK | Half-life | 10.8 | h | 10.8±2.0 | h | hepatopathy，LD; patients; | DRUGBANK | Half-life | 5.6 | h | 5.6 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 13.3 | % | 1.8-24.8 | % | Urinary excretion; | DRUGBANK | |
| Protein Binding | 57.0 | % | 28-86 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for infants | 20.0 | mg/kg/day | 20 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Lincocin | lincomycin hydrochloride | PDR |
| Max dose for children | 20.0 | mg/kg/day | 20 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Lincocin | lincomycin hydrochloride | PDR |
| Max dose for adolescents | 20.0 | mg/kg/day | 20 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Lincocin | lincomycin hydrochloride | PDR |
| Max dose for adults | 8000.0 | mg/day | 8 | g/day | intravenous injection, IV | Lincocin | lincomycin hydrochloride | PDR |
| Max dose for adults | 1200.0 | mg/day | 1.2 | g/day | IM,intramuscular injection | Lincocin | lincomycin hydrochloride | PDR |
| Max dose for geriatric | 8000.0 | mg/day | 8 | g/day | intravenous injection, IV | Lincocin | lincomycin hydrochloride | PDR |
| Max dose for geriatric | 1200.0 | mg/day | 1.2 | g/day | IM,intramuscular injection | Lincocin | lincomycin hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1