Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01611 ...
Drug Name Hydroxychloroquine
Molecular Weight 335.872
Molecular Formula C18H26ClN3O
CAS Number 118-42-3
SMILES CCN(CCO)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1
External Links
DRUGBANK DB01611
T3DB T3D3512
PubChem Compound 3652
PDR 1911
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 90.0 ℃ 89-91 ℃ U.S. Patent 2,546,658.
pKa 9.67 - 9.67 - https://watermark.silverchair.com/dkg319.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAjkwggI1BgkqhkiG9w0BBwagggImMIICIgIBADCCAhsGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMINydGQAq9Ykq8ITSAgEQgIIB7KN6oy2fz4KHncExNPnuAQKYKCeJ2g-83oHmwqGXYloWqkUp7V_gNgs5P23NTTIZEIF_Tkfp9eBMlYlDl9YykaAzqA5UdihXdzBCxmyGaNX6adn_ov0d4hq2omPSpPVCW2dnKAaalROUpR1cm7FYyTXdiDdOn2LWFKDKmA7uuEFJ1ma7-5iCQKV86x7H1W4HOu7WEBQ_dgJPGZVH64g4KrC5SEw-ekFVVL4w40J_LDqVn5mR8sS57huG_Y7d4CWhtyc6Ko27hCp_nBEeaAo95nB4odR0zFGSEASSQZXGMaO2D8zHqk1wCTDVrTLJuyzjEFMel6T-k3yZQwIVdoNxcEY1bh8VwnEz0ugIrqAkimv5xjB9m8en6H1VhrEIhOVmW2GNJGF3No03F01vn3ePhKCXzgu7v3591flqV46i7r2ZnUYNDmE39IbXww4fqX_551wAPap6lMJ0fMsD_z2l3OzHUVis9cMUJm-nC3LtunwGotVRT4Xf8s7Y-La-5NGHI9KoQPfonM-jJcQ5C9sJFkQHasuB2_a3Inu_DFo-KMOAevqW4txzmR-QnwwV13kIHkcEP03vP0ByDKcsQM2mf2py_K2JxTENhiK0B2xc30W2W4fC1HbkrT-Jd9YStj2-A83nNX0_GMFSn4DT3A

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 70.5 % 67-74 % Optical rotation R/S; DRUGBANK
C Max 50.3 ng/ml 50.3 ng/ml PO, oral; DRUGBANK
C Max 1918.0 ng/ml 1918(1161-2436) ng/ml intravenous injection, IV; DRUGBANK
C Max 1918.0 ng/ml 1918(1161-2436) ng/ml intravenous injection, IV; DRUGBANK
T Max 3.7 h 3.74 h PO, oral; DRUGBANK
Clearance 5.8 L/h 96.0 ml/min DRUGBANK
Clearance 0.66 L/h/kg 11 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 5522.0 L 5522.0 L Total volume of distribution; DRUGBANK
Volume of Distribution 44257.0 L 44257.0 L Total volume of distribution; DRUGBANK
Volume of Distribution 700.0 L/kg 700 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 3.5 h 3-4 h distribution half-life; PO, oral; DRUGBANK
Half-life 537.6 h 22.4 day PO, oral; DRUGBANK
Half-life 2964.0 h 123.5 day PO, oral; DRUGBANK
Half-life 960.0 h 40 day intravenous injection, IV; DRUGBANK
Half-life 850.0 h 850 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 45.0 % 40-50 % Urinary excretion; DRUGBANK
Eliminate Route 5.0 % 5 % slough off in skin; DRUGBANK
Eliminate Route 24.5 % 24-25 % Faeces excretion; DRUGBANK
Eliminate Route 18.5 % 16-21 % Urinary excretion; Single dose; Unchanged drug; DRUGBANK
Protein Binding 32.0 % 32 % plasma proteins; Optical rotation S; DRUGBANK
Protein Binding 16.0 % 16 % Optical rotation S; DRUGBANK
Protein Binding 9.3 % 9.28 % Optical rotation S; DRUGBANK
Protein Binding 18.5 % 18.5 % plasma proteins; Optical rotation R; DRUGBANK
Protein Binding 5.4 % 5.37 % Optical rotation R; DRUGBANK
Protein Binding 7.6 % 7.58 % Optical rotation R; DRUGBANK
Protein Binding 50.0 % 50 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for infants 13.0 mg/kg/dose 13 mg/kg/dose PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for infants 10.0 mg base/kg/dose 10 mg base/kg/dose PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for infants 16.25 mg/kg/day 16.25 mg/kg/day PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for infants 12.5 mg base/kg/day 12.5 mg base/kg/day PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for infants 0.928571428571429 mg/kg/day 6.5 mg/kg/week PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for infants 5.0 mg base/kg/week 5 mg base/kg/week PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for children 13.0 mg/kg/dose 13 mg/kg/dose PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for children 10.0 mg/kg/dose 10 mg base/kg/dose PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for children 800.0 mg 800 mg PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for children 620.0 mg base 620 mg base PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for children 16.25 mg/kg/day 16.25 mg/kg/day PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for children 12.5 mg/kg/day 12.5 mg base/kg/day PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for children 1.0 mg/day 1 mg/day PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for children 775.0 mg/day 0.775 g base/day PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for children 0.92857142 mg/kg/day 6.5 mg/kg/week PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for children 5.0 mg/kg/dose 5 mg base/kg/dose PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for children 2800.0 mg/day 400 mg/week PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for children 0.14285714 mg/day 310 mg base/week PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adolescents 13.0 mg/kg/dose 13 mg/kg/dose PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adolescents 10.0 mg base/kg/dose 10 mg base/kg/dose PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adolescents 800.0 mg 800 mg PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adolescents 620.0 mg base 620 mg base PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adolescents 16.25 mg/kg/day 16.25 mg/kg/day PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adolescents 12.5 mg base/kg/day 12.5 mg base/kg/day PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adolescents 1.0 mg/day 1 mg/day PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adolescents 0.775 g base/day 0.775 g base/day PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adolescents 0.928571428571428 mg/kg/day 6.5 mg/kg/week PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adolescents 5.0 mg base/kg/dose 5 mg base/kg/dose PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adolescents 57.1428571428571 mg/day 400 mg/week PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adolescents 310.0 mg base/week 310 mg base/week PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adults 800.0 mg/dose 800 mg/dose PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adults 620.0 mg base/dose 620 mg base/dose PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adults 1.0 mg/day 1 mg/day PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adults 0.775 g base/day 0.775 g base/day PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adults 57.1428571428571 mg/day 400 mg/week PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adults 310.0 mg base/week 310 mg base/week PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adults 85.7142857142857 mg/day 600 mg/week PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for adults 465.0 mg base/week 465 mg base/week PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for geriatric 800.0 mg/dose 800 mg/dose PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for geriatric 620.0 mg base/dose 620 mg base/dose PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for geriatric 1.0 mg/day 1 mg/day PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for geriatric 0.775 g base/day 0.775 g base/day PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for geriatric 57.1428571428571 mg/day 400 mg/week PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for geriatric 310.0 mg base/week 310 mg base/week PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for geriatric 85.7142857142857 mg/day 600 mg/week PO, oral Plaquenil hydroxychloroquine sulfate PDR
Max dose for geriatric 465.0 mg base/week 465 mg base/week PO, oral Plaquenil hydroxychloroquine sulfate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1