Basic Information
| Drug ID | DDPD01609 |
|
| Drug Name | Deferasirox | |
| Molecular Weight | 373.3615 | |
| Molecular Formula | C21H15N3O4 | |
| CAS Number | 201530-41-8 | |
| SMILES | OC(=O)C1=CC=C(C=C1)N1N=C(N=C1C1=CC=CC=C1O)C1=CC=CC=C1O | |
| External Links | ||
| DRUGBANK | DB01609 | |
| PubChem Compound | 5493381 | |
| PDR | 3707 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.52 | - | 3.52 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 116.5 | ℃ | 116-117 | ℃ | DRUGBANK |
| Water Solubility | 38.0 | mg/L | 0.038 | mg/ml | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Metabolic | 8.0 | % | 8 | % | Liver metabolism; Bile excretion; | DRUGBANK |
| Clearance | 0.0504 | L/h/kg | 0.84 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 14.4 | L | 14.37±2.69 | L | DRUGBANK | Volume of Distribution | 0.20 | L/kg | 0.2 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 12.0 | h | 8-16 | h | elimination half-life; PO, oral; | DRUGBANK | Half-life | 4.1 | h | 4.05 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 84.0 | % | 84 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 8.0 | % | 8 | % | Urinary excretion; | DRUGBANK |
| Protein Binding | 99.0 | % | ~99 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 28.0 | mg/kg/day | 28 | mg/kg/day | PO, oral | Jadenu | deferasirox | PDR |
| Max dose for children | 40.0 | mg/kg/day | 40 | mg/kg/day | PO, oral | Jadenu | deferasirox | PDR |
| Max dose for adolescents | 28.0 | mg/kg/day | 28 | mg/kg/day | PO, oral | Jadenu | deferasirox | PDR |
| Max dose for adolescents | 40.0 | mg/kg/day | 40 | mg/kg/day | PO, oral | Jadenu | deferasirox | PDR |
| Max dose for adults | 28.0 | mg/kg/day | 28 | mg/kg/day | PO, oral | Jadenu | deferasirox | PDR |
| Max dose for adults | 40.0 | mg/kg/day | 40 | mg/kg/day | PO, oral | Jadenu | deferasirox | PDR |
| Max dose for geriatric | 28.0 | mg/kg/day | 28 | mg/kg/day | PO, oral | Jadenu | deferasirox | PDR |
| Max dose for geriatric | 40.0 | mg/kg/day | 40 | mg/kg/day | PO, oral | Jadenu | deferasirox | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1