Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Boiling Point | 77.0 | ℃ | 77 | ℃ | https://www.chemicalbook.com/ChemicalProductProperty_US_CB3181854.aspx |
| Melting Point | 143.5 | ℃ | 140-147 | ℃ | https://www.caymanchem.com/msdss/17185m.pdf |
| Water Solubility | 50000.0 | mg/L | 50 | mg/ml | https://www.chemicalbook.com/ChemicalProductProperty_US_CB3181854.aspx |
| pKa | 2.1 | - | 2.1 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 24700.0 | ng.h/ml | 24.4-25 | mcg.h/ml | combination drug use; | DRUGBANK |
| C Max | 18200.0 | ng/ml | 18-18.4 | mcg/ml | combination drug use; | DRUGBANK |
| T Max | 24.0 | h | 1 | day | combination drug use; | DRUGBANK |
| Clearance | 4.0 | L/h | 48.3-83.6 | ml/min | Average clearance; intravenous injection, IV; Drug combination; renal transplant; patients; | DRUGBANK | Clearance | 0.29 | L/h/kg | 4.81 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 18.2 | L | 18.2 | L | Drug combination; | DRUGBANK | Volume of Distribution | 15.9 | L | 13.5-18.2 | L | Drug combination; | DRUGBANK | Volume of Distribution | 0.26 | L/kg | 0.26 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 0.95 | h | 0.7-1.2 | h | elimination half-life; normal,healthy; Single dose; Drug combination; | DRUGBANK | Half-life | 0.97 | h | 0.91-1.03 | h | DRUGBANK | Half-life | 0.97 | h | 0.97 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 80.0 | % | ~80 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 30.0 | % | ~30 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1