Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01601 ...
Drug Name Lopinavir
Molecular Weight 628.8008
Molecular Formula C37H48N4O5
CAS Number 192725-17-0
SMILES CC(C)[C@H](N1CCCNC1=O)C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)COC1=C(C)C=CC=C1C)CC1=CC=CC=C1
External Links
DRUGBANK DB01601
PubChem Compound 92727

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 123350.0 ng.h/ml 92.6±36.7-154.1±61.4 ug.h/ml combination drug use; DRUGBANK
Bioavailability 25.0 % ~25 % PO, oral; DRUGBANK
C Max 10800.0 ng/ml 9.8±3.7-11.8±3.7 ug/ml combination drug use; DRUGBANK
C Max 9800.0 ng/ml 9.8±3.7 mcg/ml combination drug use; The Pharmacological Basis of Therapeutics
T Max 4.4 h 4.4 h combination drug use; DRUGBANK
T Max 4.4 h 4.4±2.4 h combination drug use; The Pharmacological Basis of Therapeutics
Clearance 6.5 L/h 6.0-7 L/h apparent clearance; PO, oral; DRUGBANK
Clearance 0.0720 L/h/kg 1.2 ml/min/kg apparent clearance; AIDS,HIV; Male, men;  Female, women; The Pharmacological Basis of Therapeutics
Volume of Distribution 16.9 L ~16.9 L DRUGBANK
Volume of Distribution 0.60 L/kg 0.6 L/kg Apparent volume of distribution; AIDS,HIV; Male, men;  Female, women; The Pharmacological Basis of Therapeutics
Half-life 6.9 h 6.9±2.2 h elimination half-life; DRUGBANK
Half-life 5.3 h 5.3±2.5 h The Pharmacological Basis of Therapeutics
Eliminate Route 10.4 % 10.4±2.3 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 82.6 % 82.6±2.5 % Faeces excretion; PO, oral; DRUGBANK
Eliminate Route 2.2 % 2.2 % Urinary excretion; PO, oral; Unchanged drug; DRUGBANK
Eliminate Route 19.8 % 19.8 % Faeces excretion; PO, oral; Unchanged drug; DRUGBANK
Eliminate Route 3.0 % <3 % Urinary excretion; AIDS,HIV; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 98.0 % >98 % plasma proteins; DRUGBANK
Protein Binding 98.5 % 98-99 % AIDS,HIV; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1