Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01595 ...
Drug Name Nitrazepam
Molecular Weight 281.2661
Molecular Formula C15H11N3O3
CAS Number 146-22-5
SMILES [O-][N+](=O)C1=CC2=C(NC(=O)CN=C2C2=CC=CC=C2)C=C1
External Links
DRUGBANK DB01595
T3DB T3D3057
PubChem Compound 4506

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.25 - 2.25 - HANSCH,C ET AL. (1995)
Melting Point 225.0 ℃ 225 ℃ PhysProp
Log S -3.8 - -3.8 - ADME Research, USCD

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 73.5 % 53-94 % PO, oral; DRUGBANK
Clearance 0.0516 L/h/kg 0.86 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 1.7 L/kg 1.7 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 26.0 h 26(15-38) h elimination half-life; DRUGBANK
Half-life 26.0 h 26 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1