Basic Information
| Drug ID | DDPD01590 |
|
| Drug Name | Everolimus | |
| Molecular Weight | 958.24 | |
| Molecular Formula | C53H83NO14 | |
| CAS Number | 159351-69-6 | |
| SMILES | [H][C@@]1(C[C@@H](C)[C@]2([H])CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@]3([H])CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@@]3([H])C(=O)O2)OC)CC[C@@H](OCCO)[C@@H](C1)OC | |
| External Links | ||
| DRUGBANK | DB01590 | |
| PubChem Compound | 6442177 | |
| PDR | 416 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 1.5 | h | 1-2 | h | PO, oral; tumor; | DRUGBANK |
| Tss | 336.0 | h | 2 | week | PO, oral; | DRUGBANK |
| Half-life | 30.0 | h | ~30 | h | DRUGBANK | |
| Eliminate Route | 80.0 | % | 80 | % | Faeces excretion; Single dose; patients; human, homo sapiens; | DRUGBANK | Eliminate Route | 5.0 | % | 5 | % | Urinary excretion; Single dose; patients; human, homo sapiens; | DRUGBANK |
| Protein Binding | 74.0 | % | ~74 | % | normal,healthy; moderate hepatic impairment; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 10.0 | ng/ml | 10 | ng/ml | Afinitor | everolimus | PDR | |
| Max dose for children | 10.0 | ng/ml | 10 | ng/ml | Afinitor | everolimus | PDR | |
| Max dose for children | 10.0 | ng/ml | 10 | ng/ml | Afinitor | everolimus | PDR | |
| Max dose for adolescents | 10.0 | ng/mL | 10 | ng/mL | Afinitor | everolimus | PDR | |
| Max dose for adolescents | 10.0 | ng/mL | 10 | ng/mL | Afinitor | everolimus | PDR | |
| Max dose for adults | 10.0 | mg/day | 10 | mg/day | Afinitor | everolimus | PDR | |
| Max dose for adults | 5.5 | ng/ml | 5.5 | ng/ml | Afinitor | everolimus | PDR | |
| Max dose for adults | 10.0 | ng/ml | 10 | ng/ml | Afinitor | everolimus | PDR | |
| Max dose for adults | 10.0 | ng/ml | 10 | ng/ml | Afinitor | everolimus | PDR | |
| Max dose for geriatric | 10.0 | mg/day | 10 | mg/day | Afinitor | everolimus | PDR | |
| Max dose for geriatric | 5.5 | ng/ml | 5.5 | ng/ml | Afinitor | everolimus | PDR | |
| Max dose for geriatric | 10.0 | ng/ml | 10 | ng/ml | Afinitor | everolimus | PDR | |
| Max dose for geriatric | 10.0 | ng/ml | 10 | ng/ml | Afinitor | everolimus | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1