Basic Information
| Drug ID | DDPD01452 |
|
| Drug Name | Diamorphine | |
| Molecular Weight | 369.411 | |
| Molecular Formula | C21H23NO5 | |
| CAS Number | 561-27-3 | |
| SMILES | [H][C@@]12C=C[C@H](OC(C)=O)[C@@H]3OC4=C(OC(C)=O)C=CC5=C4[C@]13CCN(C)[C@@H]2C5 | |
| External Links | ||
| DRUGBANK | DB01452 | |
| T3DB | T3D4562 | |
| PubChem Compound | 5462328 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.58 | - | 1.58 | - | AVDEEF,A ET AL. (1996) |
| Boiling Point | 273.0 | ℃ | 272-274 | ℃ | PhysProp |
| Melting Point | 173.0 | ℃ | 173 | ℃ | PhysProp |
| Water Solubility | 600.0 | mg/L | 600 | mg/L | SEIDELL,A 1941) |
| pKa | 7.95 | - | 7.95 | - | AVDEEF,A ET AL. (1996) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 35.0 | % | <35 | % | PO, oral; | DRUGBANK | Bioavailability | 22.9 | % | 22.9(16.4-29.4) | % | PO, oral; different study; | DRUGBANK |
| T Max | 0.13 | h | 5-10 | min | subcutaneous injection, SC; | DRUGBANK | T Max | 0.0667 | h | 3-5 | min | IM,intramuscular injection; | DRUGBANK | T Max | 0.0667 | h | 3-5 | min | intranasal; | DRUGBANK | T Max | 0.0167 | h | <1 | min | intravenous injection, IV; | DRUGBANK |
| Clearance | 522.0 | L/h | 8.7±2.6 | L/min | Total clearance; | DRUGBANK |
| Volume of Distribution | 3.5 | L/kg | 1.0-6 | L/kg | DRUGBANK | |
| Half-life | 0.0417 | h | 2-3 | min | human, homo sapiens; | DRUGBANK |
| Eliminate Route | 8.5 | % | 7-10 | % | Faeces excretion; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1