Basic Information
| Drug ID | DDPD01438 |
|
| Drug Name | Phenazopyridine | |
| Molecular Weight | 213.2385 | |
| Molecular Formula | C11H11N5 | |
| CAS Number | 94-78-0 | |
| SMILES | NC1=NC(N)=C(C=C1)\N=N\C1=CC=CC=C1 | |
| External Links | ||
| DRUGBANK | DB01438 | |
| PubChem Compound | 4756 | |
| PDR | 3457 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.62 | - | 2.62 | - | https://pdfs.semanticscholar.org/182c/23f8f9a5935f172b01241dd7c06d8d72b6f3.pdf |
| Boiling Point | 442.3 | ℃ | 442.3 | ℃ | https://www.lookchem.com/Phenazopyridine-hydrochloride/ |
| Melting Point | 139.0 | ℃ | 139 | ℃ | https://www.lookchem.com/Phenazopyridine-hydrochloride/ |
| pKa | 5.05 | - | 5.05 | - | https://pdfs.semanticscholar.org/182c/23f8f9a5935f172b01241dd7c06d8d72b6f3.pdf |
| Log S | 3.83 | - | 3.83 | - | https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/phenazopyridine |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 431.8 | ng.h/ml | 431.77±87.82 | ng.h/ml | DRUGBANK | |
| C Max | 65.0 | ng/ml | 65.00±29.23 | ng/ml | DRUGBANK | |
| T Max | 2.5 | h | 2.48±0.50 | h | DRUGBANK | |
| Metabolic | 41.0 | % | 41 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Half-life | 7.4 | h | 7.35 | h | elimination half-life; normal renal function; Rattus, Rat; | DRUGBANK |
| Toxicity LD50 | 472.0 | mg/kg | 472.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Eliminate Route | 90.0 | % | 90 | % | PO, oral; normal,healthy; human, homo sapiens; | DRUGBANK | Eliminate Route | 80.1 | % | 80.07±4.54 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 40.7 | % | 40.7 | % | Bile excretion; Rattus, Rat; | DRUGBANK | Eliminate Route | 65.0 | % | 65 | % | Urinary excretion; PO, oral; Unchanged drug; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 600.0 | mg/day | 600 | mg/day | PO, oral | Pyridium | phenazopyridine hydrochloride | PDR |
| Max dose for children | 12.0 | mg/kg/day | 12 | mg/kg/day | PO, oral | Pyridium | phenazopyridine hydrochloride | PDR |
| Max dose for adolescents | 600.0 | mg/day | 600 | mg/day | PO, oral | Pyridium | phenazopyridine hydrochloride | PDR |
| Max dose for adults | 600.0 | mg/day | 600 | mg/day | PO, oral | Pyridium | phenazopyridine hydrochloride | PDR |
| Max dose for geriatric | 600.0 | mg/day | 600 | mg/day | PO, oral | Pyridium | phenazopyridine hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1