Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.98 | - | 1.98 | - | SANGSTER (1994) |
| Melting Point | 197.5 | ℃ | 196-199 | ℃ | Merck Index 23 |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 60.0 | % | >60 | % | PO, oral; | DRUGBANK |
| T Max | 2.0 | h | 1-3 | h | PO, oral; | DRUGBANK |
| Clearance | 0.0768 | L/h/kg | 1.28 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.0780 | L/kg | 78.0 | ml/kg | at steady state; | DRUGBANK | Volume of Distribution | 0.0880 | L/kg | 88.0 | ml/kg | at steady state; | DRUGBANK | Volume of Distribution | 0.24 | L/kg | 0.24 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 9.5 | h | 8-11 | h | DRUGBANK | Half-life | 7.2 | h | 7.22 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 1470.0 | mg/kg | 1470.0 | mg/kg | PO, oral; mouse; | T3DB | Toxicity LD50 | 115.0 | mg/kg | 115.0 | mg/kg | Intraperitoneal, IP; mouse; | T3DB |
| Protein Binding | 98.7 | % | 98.7 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1