Basic Information
| Drug ID | DDPD01400 |
|
| Drug Name | Neostigmine | |
| Molecular Weight | 223.2915 | |
| Molecular Formula | C12H19N2O2 | |
| CAS Number | 59-99-4 | |
| SMILES | CN(C)C(=O)OC1=CC(=CC=C1)[N+](C)(C)C | |
| External Links | ||
| DRUGBANK | DB01400 | |
| PubChem Compound | 4456 | |
| PDR | 3265 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| C Max | 275.0 | ng/ml | 200-350 | ng/ml | patients; | The Pharmacological Basis of Therapeutics | |
| Clearance | 1.0 | L/h/kg | 16.7±5.4 | ml/min/kg | RD, renal impairment, Renal disease，including uremia ↓ ; | The Pharmacological Basis of Therapeutics | Clearance | 0.55 | L/h/kg | 9.2 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.4 | L/kg | 1.4±0.5 | L/kg | The Pharmacological Basis of Therapeutics | Volume of Distribution | 0.74 | L/kg | 0.74 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 0.87 | h | 52(42-60) | min | DRUGBANK | Half-life | 1.3 | h | 1.3±0.8 | h | RD, renal impairment, Renal disease，including uremia ↑ ; | The Pharmacological Basis of Therapeutics | Half-life | 1.3 | h | 1.3 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 0.30 | mg/kg | 0.3±0.02 | mg/kg | intravenous injection, IV; mouse; | DRUGBANK | Toxicity LD50 | 0.54 | mg/kg | 0.54±0.03 | mg/kg | subcutaneous injection, SC; mouse; | DRUGBANK | Toxicity LD50 | 0.40 | mg/kg | 0.395±0.025 | mg/kg | IM,intramuscular injection; mouse; | DRUGBANK | Toxicity LD50 | 0.32 | mg/kg | 0.315±0.019 | mg/kg | intravenous injection, IV; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 0.45 | mg/kg | 0.445±0.032 | mg/kg | subcutaneous injection, SC; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 0.42 | mg/kg | 0.423±0.032 | mg/kg | IM,intramuscular injection; Rattus, Rat; | DRUGBANK |
| Eliminate Route | 67.0 | % | 67 | % | Urinary excretion; Unchanged drug; | The Pharmacological Basis of Therapeutics | |
| Protein Binding | 20.0 | % | 15-25 | % | human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 0.07 | mg/kg | 0.07 | mg/kg | intravenous injection, IV | Bloxiverz | neostigmine methylsulfate | PDR |
| Max dose for infants | 0.07 | mg/kg | 0.07 | mg/kg | intravenous injection, IV | Bloxiverz | neostigmine methylsulfate | PDR |
| Max dose for children | 0.07 | mg/kg | 0.07 | mg/kg | intravenous injection, IV | Bloxiverz | neostigmine methylsulfate | PDR |
| Max dose for children | 5.0 | mg | 5 | mg | intravenous injection, IV | Bloxiverz | neostigmine methylsulfate | PDR |
| Max dose for adolescents | 0.07 | mg/kg | 0.07 | mg/kg | intravenous injection, IV | Bloxiverz | neostigmine methylsulfate | PDR |
| Max dose for adolescents | 5.0 | mg | 5 | mg | intravenous injection, IV | Bloxiverz | neostigmine methylsulfate | PDR |
| Max dose for adults | 375.0 | mg/day | 375 | mg/day | PO, oral | Bloxiverz | neostigmine methylsulfate | PDR |
| Max dose for adults | 0.5 | mg | 0.5 | mg | IM,intramuscular injection;subcutaneous injection, SC; | Bloxiverz | neostigmine methylsulfate | PDR |
| Max dose for adults | 0.07 | mg/kg | 0.07 | mg/kg | intravenous injection, IV | Bloxiverz | neostigmine methylsulfate | PDR |
| Max dose for adults | 5.0 | mg | 5 | mg | intravenous injection, IV | Bloxiverz | neostigmine methylsulfate | PDR |
| Max dose for geriatric | 375.0 | mg/day | 375 | mg/day | PO, oral | Bloxiverz | neostigmine methylsulfate | PDR |
| Max dose for geriatric | 0.5 | mg | 0.5 | mg | IM,intramuscular injection;subcutaneous injection, SC; | Bloxiverz | neostigmine methylsulfate | PDR |
| Max dose for geriatric | 0.07 | mg/kg | 0.07 | mg/kg | intravenous injection, IV | Bloxiverz | neostigmine methylsulfate | PDR |
| Max dose for geriatric | 5.0 | mg | 5 | mg | intravenous injection, IV | Bloxiverz | neostigmine methylsulfate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1