Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01337 ...
Drug Name Pancuronium
Molecular Weight 572.8619
Molecular Formula C35H60N2O4
CAS Number 16974-53-1
SMILES [H][C@@]12C[C@@H]([C@H](OC(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@H](OC(C)=O)[C@H](C[C@]12C)[N+]1(C)CCCCC1)[N+]1(C)CCCCC1
External Links
DRUGBANK DB01337
PubChem Compound 441289

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 215.0 ℃ 215 ℃ PhysProp
Water Solubility 500000.0 mg/L 500000 mg/L MERCK INDEX 1996)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
C Max 670.0 ng/ml 0.67 mcg/ml intravenous injection, IV; surgery; The Pharmacological Basis of Therapeutics
Clearance 0.0900 L/h/kg 1.1–1.9 ml/min/kg Plasma clearance; DRUGBANK
Clearance 0.11 L/h/kg 1.8±0.4 ml/min/kg Elderly ↓ ;Hepatic cirrhosis, cirr → ;RD, renal impairment, Renal disease，including uremia ↓ ;CPBS → ; The Pharmacological Basis of Therapeutics
Clearance 0.0900 L/h/kg 1.5 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.26 L/kg 241-280 ml/kg DRUGBANK
Volume of Distribution 0.26 L/kg 0.26±0.07 L/kg Elderly → ;Hepatic cirrhosis, cirr ↑ ;RD, renal impairment, Renal disease，including uremia → ;CPBS → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.20 L/kg 0.2 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.1 h 1.5-2.7 h DRUGBANK
Half-life 2.3 h 2.3±0.4 h RD, renal impairment, Renal disease，including uremia ↑ ;Hepatic cirrhosis, cirr ↑ ;RD, renal impairment, Renal disease，including uremia ↓ ;CPBS → ;Age ↑ ;Age ↓ ; The Pharmacological Basis of Therapeutics
Half-life 1.9 h 1.9 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 67.0 % 67±18 % Urinary excretion; Unchanged drug; CPBS → ; The Pharmacological Basis of Therapeutics
Protein Binding 84.0 % 77-91 % DRUGBANK
Protein Binding 7.0 % 7±2 % Neonates → ; Female, women → ;Preg, pregnant → ;RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1