Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01331 ...
Drug Name Cefoxitin
Molecular Weight 427.452
Molecular Formula C16H17N3O7S2
CAS Number 35607-66-0
SMILES [H][C@]12SCC(COC(N)=O)=C(N1C(=O)[C@]2(NC(=O)CC1=CC=CS1)OC)C(O)=O
External Links
DRUGBANK DB01331
PubChem Compound 441199
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -0.02 - -0.02 - SANGSTER (1993)
Melting Point 166.0 ℃ 165-167 ℃ Christiansen, B.G. and Firestone, R.A.; US. Patent 3,775,410; November 27, 1973; assigned Hazen, G.C.; U.S. Patent 3,780,033; December 18, 1973; assigned to Merck & Company, Inc.

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Metabolic 85.0 % 85 % Urinary excretion; Unchanged drug; DRUGBANK
Clearance 0.22 L/h/kg 3.6 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.17 L/kg 0.17 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 0.83 h 41-59 min intravenous injection, IV; DRUGBANK
Half-life 0.81 h 0.81 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 8000.0 mg/kg ~8 g/kg intravenous injection, IV; adults; female mouse; DRUGBANK
Toxicity LD50 1000.0 mg/kg >1 g/kg intravenous injection, IV; adults; rabbit; DRUGBANK
Toxicity LD50 10000.0 mg/kg >10 g/kg Intraperitoneal, IP; adults; Rattus, Rat; DRUGBANK
Eliminate Route 85.0 % ~85 % Urinary excretion; Unchanged drug; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1