Basic Information
| Drug ID | DDPD01330 |
|
| Drug Name | Cefotetan | |
| Molecular Weight | 575.619 | |
| Molecular Formula | C17H17N7O8S4 | |
| CAS Number | 69712-56-7 | |
| SMILES | [H][C@]12SCC(CSC3=NN=NN3C)=C(N1C(=O)[C@]2(NC(=O)C1SC(S1)=C(C(N)=O)C(O)=O)OC)C(O)=O | |
| External Links | ||
| DRUGBANK | DB01330 | |
| PubChem Compound | 53025 | |
| PDR | 3448 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| C Max | 91000.0 | ng/ml | 91.0 | mcg/ml | adults; normal,healthy; | The Pharmacological Basis of Therapeutics | C Max | 413500.0 | ng/ml | 336-491 | mcg/ml | adults; normal,healthy; | The Pharmacological Basis of Therapeutics | C Max | 38000.0 | ng/ml | 38.0 | mcg/ml | adults; normal,healthy; | The Pharmacological Basis of Therapeutics |
| T Max | 2.3 | h | 1.5-3 | h | adults; normal,healthy; | The Pharmacological Basis of Therapeutics | |
| Clearance | 1.8 | L/h | 1.8±0.1 | L/h | Geriatric; normal renal function; | DRUGBANK | Clearance | 1.8 | L/h | 1.8±0.3 | L/h | normal,healthy; young; | DRUGBANK | Clearance | 0.0252 | L/h/kg | 0.42 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 10.4 | L | 10.4 | L | normal renal function; Geriatric; | DRUGBANK | Volume of Distribution | 10.3 | L | 10.3 | L | normal,healthy; adults; | DRUGBANK | Volume of Distribution | 0.14 | L/kg | 0.14±0.03 | L/kg | RD, renal impairment, Renal disease，including uremia → ; | The Pharmacological Basis of Therapeutics | Volume of Distribution | 0.13 | L/kg | 0.13 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 3.6 | h | 3.6±1.0 | h | RD, renal impairment, Renal disease，including uremia ↑ ; | The Pharmacological Basis of Therapeutics | Half-life | 4.5 | h | 4.5 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 67.0 | % | 67±11 | % | Urinary excretion; Unchanged drug; | The Pharmacological Basis of Therapeutics | |
| Protein Binding | 88.0 | % | 88 | % | plasma proteins; | DRUGBANK | Protein Binding | 85.0 | % | 85±4 | % | The Pharmacological Basis of Therapeutics |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for infants | 100.0 | mg/kg/day | 100 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Cefotetan | cefotetan disodium | PDR |
| Max dose for children | 100.0 | mg/kg/day | 100 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Cefotetan | cefotetan disodium | PDR |
| Max dose for children | 6000.0 | mg/day | 6 | g/day | intravenous injection, IV | Cefotetan | cefotetan disodium | PDR |
| Max dose for children | 4000.0 | mg/day | 4 | g/day | IM,intramuscular injection | Cefotetan | cefotetan disodium | PDR |
| Max dose for adolescents | 100.0 | mg/kg/day | 100 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Cefotetan | cefotetan disodium | PDR |
| Max dose for adolescents | 6000.0 | mg/day | 6 | g/day | intravenous injection, IV | Cefotetan | cefotetan disodium | PDR |
| Max dose for adolescents | 4000.0 | mg/day | 4 | g/day | IM,intramuscular injection | Cefotetan | cefotetan disodium | PDR |
| Max dose for adults | 6000.0 | mg/day | 6 | g/day | intravenous injection, IV | Cefotetan | cefotetan disodium | PDR |
| Max dose for adults | 4000.0 | mg/day | 4 | g/day | IM,intramuscular injection | Cefotetan | cefotetan disodium | PDR |
| Max dose for geriatric | 6000.0 | mg/day | 6 | g/day | intravenous injection, IV | Cefotetan | cefotetan disodium | PDR |
| Max dose for geriatric | 4000.0 | mg/day | 4 | g/day | IM,intramuscular injection | Cefotetan | cefotetan disodium | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1