Basic Information
| Drug ID | DDPD01327 |
|
| Drug Name | Cefazolin | |
| Molecular Weight | 454.507 | |
| Molecular Formula | C14H14N8O4S3 | |
| CAS Number | 25953-19-9 | |
| SMILES | [H][C@]12SCC(CSC3=NN=C(C)S3)=C(N1C(=O)[C@H]2NC(=O)CN1C=NN=N1)C(O)=O | |
| External Links | ||
| DRUGBANK | DB01327 | |
| PubChem Compound | 33255 | |
| PDR | 1193 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -0.58 | - | -0.58 | - | HANSCH,C ET AL. (1995) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Bioavailability | 90.0 | % | >90 | % | PO, oral; | The Pharmacological Basis of Therapeutics | |
| C Max | 42000.0 | ng/ml | 42±9.5 | mcg/ml | The Pharmacological Basis of Therapeutics | C Max | 237000.0 | ng/ml | 237±285 | mcg/ml | The Pharmacological Basis of Therapeutics |
| T Max | 1.5 | h | 1-2 | h | IM,intramuscular injection; | DRUGBANK | T Max | 1.7 | h | 1.7±0.7 | h | The Pharmacological Basis of Therapeutics |
| Metabolic | 0 | % | 0 | % | DRUGBANK | ||
| Clearance | 0.0570 | L/h/kg | 0.95±0.17 | ml/min/kg | Neonates → ;Children → ;Preg, pregnant ↑ ;Hepatitis, Hep → ;RD, renal impairment, Renal disease，including uremia ↓ ;Obesity → ;CPBS ↓ ; | The Pharmacological Basis of Therapeutics | Clearance | 0.0534 | L/h/kg | 0.89 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.19 | L/kg | 0.19±0.06 | L/kg | Neonates ↑ ;Children → ;Preg, pregnant → ;Hepatitis, Hep → ;RD, renal impairment, Renal disease，including uremia ↑ ;Obesity → ; | The Pharmacological Basis of Therapeutics | Volume of Distribution | 0.12 | L/kg | 0.12 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 1.8 | h | ~1.8 | h | elimination half-life; intravenous injection, IV; | DRUGBANK | Half-life | 2.0 | h | ~2 | h | elimination half-life; IM,intramuscular injection; | DRUGBANK | Half-life | 2.2 | h | 2.2±0.02 | h | Neonates ↑ ;Preg, pregnant ↓ ;Children → ;RD, renal impairment, Renal disease，including uremia ↑ ;CPBS ↑ ;Hepatic cirrhosis, cirr ↓ ;Obesity → ; | The Pharmacological Basis of Therapeutics | Half-life | 1.7 | h | 1.7 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 60.0 | % | ~60 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 75.0 | % | 70-80 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 80.0 | % | 80±16 | % | Urinary excretion; Unchanged drug; | The Pharmacological Basis of Therapeutics |
| Protein Binding | 80.0 | % | 74-86 | % | DRUGBANK | Protein Binding | 89.0 | % | 89±2 | % | Neonates ↓ ;Children ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ;Hepatic cirrhosis, cirr ↓ ;CPBS ↓ ; | The Pharmacological Basis of Therapeutics |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 150.0 | mg/kg/day | 150 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Cefazolin Sodium | cefazolin sodium | PDR |
| Max dose for neonates | 100.0 | mg/kg/day | 100 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Cefazolin Sodium | cefazolin sodium | PDR |
| Max dose for neonates | 150.0 | mg/kg/day | 150 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Cefazolin Sodium | cefazolin sodium | PDR |
| Max dose for neonates | 100.0 | mg/kg/day | 100 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Cefazolin Sodium | cefazolin sodium | PDR |
| Max dose for infants | 100.0 | mg/kg/day | 100 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Cefazolin Sodium | cefazolin sodium | PDR |
| Max dose for infants | 150.0 | mg/kg/day | 150 | mg/kg/day | intravenous injection, IV | Cefazolin Sodium | cefazolin sodium | PDR |
| Max dose for children | 100.0 | mg/kg/day | 100 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Cefazolin Sodium | cefazolin sodium | PDR |
| Max dose for children | 6000.0 | mg/day | 6 | g/day | intravenous injection, IV;IM,intramuscular injection; | Cefazolin Sodium | cefazolin sodium | PDR |
| Max dose for children | 150.0 | mg/kg/day | 150 | mg/kg/day | intravenous injection, IV | Cefazolin Sodium | cefazolin sodium | PDR |
| Max dose for children | 12000.0 | mg/day | 12 | g/day | intravenous injection, IV | Cefazolin Sodium | cefazolin sodium | PDR |
| Max dose for adolescents | 100.0 | mg/kg/day | 100 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Cefazolin Sodium | cefazolin sodium | PDR |
| Max dose for adolescents | 6000.0 | mg/day | 6 | g/day | intravenous injection, IV;IM,intramuscular injection; | Cefazolin Sodium | cefazolin sodium | PDR |
| Max dose for adolescents | 150.0 | mg/kg/day | 150 | mg/kg/day | intravenous injection, IV | Cefazolin Sodium | cefazolin sodium | PDR |
| Max dose for adolescents | 12000.0 | mg/day | 12 | g/day | intravenous injection, IV | Cefazolin Sodium | cefazolin sodium | PDR |
| Max dose for adults | 12000.0 | mg/day | 12 | g/day | intravenous injection, IV;IM,intramuscular injection; | Cefazolin Sodium | cefazolin sodium | PDR |
| Max dose for geriatric | 12000.0 | mg/day | 12 | g/day | intravenous injection, IV;IM,intramuscular injection; | Cefazolin Sodium | cefazolin sodium | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1