Basic Information
| Drug ID | DDPD01275 |
|
| Drug Name | Hydralazine | |
| Molecular Weight | 160.1759 | |
| Molecular Formula | C8H8N4 | |
| CAS Number | 86-54-4 | |
| SMILES | NNC1=NN=CC2=CC=CC=C12 | |
| External Links | ||
| DRUGBANK | DB01275 | |
| PubChem Compound | 3637 | |
| PDR | 738 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.0 | - | 1.0 | - | SANGSTER (1993) |
| Boiling Point | 251.3 | ℃ | 251.3 | ℃ | ChemSpider |
| Melting Point | 172.5 | ℃ | 172-173 | ℃ | U.S. Patent 2,484,029. |
| Water Solubility | 1000.0 | mg/L | <1 | mg/ml | ChemSpider |
| pKa | 7.3 | - | 7.3 | - | Machado (2002) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 93903.1 | ng.h | 17.5-29.4 | uM.min | PO, oral; | DRUGBANK | AUC | 45917.1 | ng.h | 4.0-30.4 | uM.min | PO, oral; | DRUGBANK |
| C Max | 114.5 | mg/ml | 0.12-1.31 | uM | PO, oral; patients; | DRUGBANK |
| Clearance | 1.8 | L/h/kg | 1.77±0.48 | L/kg/h | Average clearance; heart disease; | DRUGBANK | Clearance | 2.6 | L/h/kg | 42.7±8.9 | ml/min/kg | Average clearance; hypertension; | DRUGBANK | Clearance | 5.1 | L/h/kg | 85 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.3 | L/kg | 1.34±0.79 | L/kg | heart disease; patients; | DRUGBANK | Volume of Distribution | 2.0 | L/kg | 1.98±0.22 | L/kg | hypertension; patients; | DRUGBANK | Volume of Distribution | 1.5 | L/kg | 1.5 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 5.0 | h | 2.2-7.8 | h | fast acetylators; | DRUGBANK | Half-life | 3.9 | h | 2.0-5.8 | h | Slow acetylators; | DRUGBANK | Half-life | 1.8 | h | 105(57-241) | min | heart failure; patients; | DRUGBANK | Half-life | 3.3 | h | 200 | min | hypertension; fast acetylators; | DRUGBANK | Half-life | 5.0 | h | 297 | min | hypertension; Slow acetylators; | DRUGBANK | Half-life | 1.0 | h | 1 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 180.0 | mg/kg | 173-187 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Eliminate Route | 10.0 | % | <10 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 77.5 | % | 65-90 | % | Urinary excretion; | DRUGBANK |
| Protein Binding | 87.0 | % | 87 | % | human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 7.5 | mg/kg/day | 7.5 | mg/kg/day | PO, oral | Hydralazine Hydrochloride Tablets | hydralazine hydrochloride | PDR |
| Max dose for neonates | 0.6 | mg/kg/dose | 0.6 | mg/kg/dose | intravenous injection, IV | Hydralazine Hydrochloride Tablets | hydralazine hydrochloride | PDR |
| Max dose for infants | 7.5 | mg/kg/day | 7.5 | mg/kg/day | PO, oral | Hydralazine Hydrochloride Tablets | hydralazine hydrochloride | PDR |
| Max dose for infants | 3.5 | mg/kg/day | 3.5 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Hydralazine Hydrochloride Tablets | hydralazine hydrochloride | PDR |
| Max dose for children | 7.5 | mg/kg/day | 7.5 | mg/kg/day | PO, oral | Hydralazine Hydrochloride Tablets | hydralazine hydrochloride | PDR |
| Max dose for children | 200.0 | mg/day | 200 | mg/day | PO, oral | Hydralazine Hydrochloride Tablets | hydralazine hydrochloride | PDR |
| Max dose for children | 3.5 | mg/kg/day | 3.5 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Hydralazine Hydrochloride Tablets | hydralazine hydrochloride | PDR |
| Max dose for adolescents | 7.5 | mg/kg/day | 7.5 | mg/kg/day | PO, oral | Hydralazine Hydrochloride Tablets | hydralazine hydrochloride | PDR |
| Max dose for adolescents | 200.0 | mg/day | 200 | mg/day | PO, oral | Hydralazine Hydrochloride Tablets | hydralazine hydrochloride | PDR |
| Max dose for adolescents | 3.5 | mg/kg/day | 3.5 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Hydralazine Hydrochloride Tablets | hydralazine hydrochloride | PDR |
| Max dose for adults | 300.0 | mg/day | 300 | mg/day | PO, oral | Hydralazine Hydrochloride Tablets | hydralazine hydrochloride | PDR |
| Max dose for adults | 250.0 | mg/day | 250 | mg/day | PO, oral | Hydralazine Hydrochloride Tablets | hydralazine hydrochloride | PDR |
| Max dose for geriatric | 300.0 | mg/day | 300 | mg/day | PO, oral | Hydralazine Hydrochloride Tablets | hydralazine hydrochloride | PDR |
| Max dose for geriatric | 250.0 | mg/day | 250 | mg/day | PO, oral | Hydralazine Hydrochloride Tablets | hydralazine hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1