Basic Information
| Drug ID | DDPD01267 |
|
| Drug Name | Paliperidone | |
| Molecular Weight | 426.4839 | |
| Molecular Formula | C23H27FN4O3 | |
| CAS Number | 144598-75-4 | |
| SMILES | CC1=C(CCN2CCC(CC2)C2=NOC3=C2C=CC(F)=C3)C(=O)N2CCCC(O)C2=N1 | |
| External Links | ||
| DRUGBANK | DB01267 | |
| PubChem Compound | 115237 | |
| PDR | 269 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.8 | - | 1.8 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 28.0 | % | 28 | % | PO, oral; | DRUGBANK |
| Clearance | 0.0708 | L/h/kg | 1.18 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 487.0 | L | 487.0 | L | DRUGBANK | |
| Half-life | 23.0 | h | ~23 | h | elimination half-life; | DRUGBANK | Half-life | 24.6 | h | 24.6 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 59.0 | % | 59(51-67) | % | Urinary excretion; Oral single dose; normal,healthy; human, homo sapiens; Unchanged drug; | DRUGBANK |
| Protein Binding | 74.0 | % | 74 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 12.0 | mg/day | 12 | mg/day | PO, oral | Invega | paliperidone | PDR |
| Max dose for children | 6.0 | mg/day | 6 | mg/day | PO, oral | Invega | paliperidone | PDR |
| Max dose for adolescents | 12.0 | mg/day | 12 | mg/day | PO, oral | Invega | paliperidone | PDR |
| Max dose for adolescents | 6.0 | mg/day | 6 | mg/day | PO, oral | Invega | paliperidone | PDR |
| Max dose for adults | 12.0 | mg/day | 12 | mg/day | Tablet,PO，oral | Invega | paliperidone | PDR |
| Max dose for adults | 7.8 | mg/day | 234 | mg/month | IM,intramuscular injection | Invega | paliperidone | PDR |
| Max dose for adults | 9.1 | mg/day | 819 | mg/3 months | IM,intramuscular injection | Invega | paliperidone | PDR |
| Max dose for geriatric | 12.0 | mg/day | 12 | mg/day | Tablet,PO，oral | Invega | paliperidone | PDR |
| Max dose for geriatric | 7.8 | mg/day | 234 | mg/month | IM,intramuscular injection | Invega | paliperidone | PDR |
| Max dose for geriatric | 9.1 | mg/day | 819 | mg/3 months | IM,intramuscular injection | Invega | paliperidone | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1