Basic Information
| Drug ID | DDPD01265 |
|
| Drug Name | Telbivudine | |
| Molecular Weight | 242.2286 | |
| Molecular Formula | C10H14N2O5 | |
| CAS Number | 3424-98-4 | |
| SMILES | CC1=CN([C@@H]2C[C@@H](O)[C@H](CO)O2)C(=O)NC1=O | |
| External Links | ||
| DRUGBANK | DB01265 | |
| PubChem Compound | 159269 | |
| PDR | 1242 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -1.4 | - | -1.4 | - | DRUGBANK |
| Water Solubility | 20000.0 | mg/L | >20 | mg/ml | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 7.6 | L/h | 7.6±2.9 | L/h | normal renal function; | DRUGBANK | Clearance | 5.0 | L/h | 5.0±1.2 | L/h | mild renal function; | DRUGBANK | Clearance | 2.6 | L/h | 2.6±1.2 | L/h | moderate renal function; | DRUGBANK | Clearance | 0.70 | L/h | 0.7±0.4 | L/h | severe renal function; | DRUGBANK |
| Half-life | 15.0 | h | ~15 | h | DRUGBANK | |
| Protein Binding | 3.3 | % | 3.3 | % | plasma proteins; high protein binding; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for adolescents | 600.0 | mg/day | 600 | mg/day | PO, oral | qd | Tyzeka | telbivudine | PDR |
| Max dose for adults | 600.0 | mg/day | 600 | mg/day | PO, oral | qd | Tyzeka | telbivudine | PDR |
| Max dose for geriatric | 600.0 | mg/day | 600 | mg/day | PO, oral | qd | Tyzeka | telbivudine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1