Basic Information
| Drug ID | DDPD01262 |
|
| Drug Name | Decitabine | |
| Molecular Weight | 228.2053 | |
| Molecular Formula | C8H12N4O4 | |
| CAS Number | 2353-33-5 | |
| SMILES | NC1=NC(=O)N(C=N1)[C@H]1C[C@H](O)[C@@H](CO)O1 | |
| External Links | ||
| DRUGBANK | DB01262 | |
| PubChem Compound | 451668 | |
| PDR | 140 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 125.0 | L/h/m2 | 125.0 | L/h/m2 | intravenous infusion, IV in drop; patients; | DRUGBANK | Clearance | 210.0 | L/h/m2 | 210.0 | L/h/m2 | intravenous infusion, IV in drop; | DRUGBANK | Clearance | 7.8 | L/h/kg | 130 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 4.6 | L/kg | 4.6 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 0.51 | h | 0.51±0.31 | h | elimination half-life; | DRUGBANK | Half-life | 0.58 | h | 0.58 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 1.0 | % | <1 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 15.0 | mg/m2/day | 15 | mg/m2/day | intravenous injection, IV | Dacogen | decitabine | PDR |
| Max dose for adults | 135.0 | mg/m2/cycLe | 135 | mg/m2/cycLe | intravenous injection, IV | Dacogen | decitabine | PDR |
| Max dose for adults | 20.0 | mg/m2/day | 20 | mg/m2/day | intravenous injection, IV | Dacogen | decitabine | PDR |
| Max dose for geriatric | 15.0 | mg/m2/day | 15 | mg/m2/day | intravenous injection, IV | Dacogen | decitabine | PDR |
| Max dose for geriatric | 135.0 | mg/m2/cycle | 135 | mg/m2/cycle | intravenous injection, IV | Dacogen | decitabine | PDR |
| Max dose for geriatric | 50.0 | mg/m2/day | 50 | mg/m2/day | intravenous injection, IV | Dacogen | decitabine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1