Basic Information
| Drug ID | DDPD01259 |
|
| Drug Name | Lapatinib | |
| Molecular Weight | 581.058 | |
| Molecular Formula | C29H26ClFN4O4S | |
| CAS Number | 231277-92-2 | |
| SMILES | CS(=O)(=O)CCNCC1=CC=C(O1)C1=CC2=C(C=C1)N=CN=C2NC1=CC(Cl)=C(OCC2=CC(F)=CC=C2)C=C1 | |
| External Links | ||
| DRUGBANK | DB01259 | |
| PubChem Compound | 208908 | |
| PDR | 232 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 5.4 | - | 5.4 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Half-life | 14.2 | h | 14.2 | h | terminal half-life; Single dose; | DRUGBANK | Half-life | 24.0 | h | 24 | h | effective half-life; Multiple dose; | DRUGBANK |
| Protein Binding | 99.0 | % | 99 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 1500.0 | mg/day | 1500 | mg/day | PO, oral | qd | Tykerb | lapatinib | PDR |
| Max dose for geriatric | 1500.0 | mg/day | 1500 | mg/day | PO, oral | qd | Tykerb | lapatinib | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1