Basic Information
| Drug ID | DDPD01255 |
|
| Drug Name | Lisdexamfetamine | |
| Molecular Weight | 263.3785 | |
| Molecular Formula | C15H25N3O | |
| CAS Number | 608137-32-2 | |
| SMILES | C[C@@H](CC1=CC=CC=C1)NC(=O)[C@@H](N)CCCCN | |
| External Links | ||
| DRUGBANK | DB01255 | |
| PubChem Compound | 11597698 | |
| PDR | 538 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -1.76 | - | -1.76 | - | https://www.tga.gov.au/sites/.../auspar-lisdexamfetamine-dimesilate-131023-pi.docx |
| Water Solubility | 792000.0 | mg/L | 792 | mg/ml | FDA label |
| pKa | 10.5 | - | 10.5 | - | https://www.tga.gov.au/sites/.../auspar-lisdexamfetamine-dimesilate-131023-pi.docx |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 1.0 | h | 1 | h | Tablet, PO, oral; normal,healthy; fasting; | DRUGBANK | T Max | 4.4 | h | 4.4 | h | Tablet, PO, oral; normal,healthy; fasting; Active metabolite; | DRUGBANK | T Max | 1.0 | h | 1 | h | Capsule, PO, Oral; Children; fasting; Attention deficit hyperactivity disorder; | DRUGBANK | T Max | 3.5 | h | 3.5 | h | Capsule, PO, Oral; Children; fasting; Attention deficit hyperactivity disorder; Active metabolite; | DRUGBANK |
| Clearance | 0.63 | L/h/kg | 0.55-0.7 | l/h/kg | Elderly; | DRUGBANK | Clearance | 1.0 | L/h/kg | 17 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.60 | L/kg | 0.6 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 12.0 | h | ~12 | h | elimination half-life; PO, oral; | DRUGBANK | Half-life | 1.0 | h | <1 | h | elimination half-life; Single dose; | DRUGBANK | Half-life | 1.2 | h | 1.2 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 7060.0 | mg/kg | 7060.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 3450.0 | mg/kg | 3450.0 | mg/kg | PO, oral; mouse; | DRUGBANK |
| Eliminate Route | 96.0 | % | 96 | % | Urinary excretion; PO, oral; normal,healthy; human, homo sapiens; | DRUGBANK | Eliminate Route | 0.30 | % | 0.3 | % | Faeces excretion; PO, oral; normal,healthy; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 70.0 | mg/day | 70 | mg/day | PO, oral | Vyvanse | lisdexamfetamine dimesylate | PDR |
| Max dose for adolescents | 70.0 | mg/day | 70 | mg/day | PO, oral | Vyvanse | lisdexamfetamine dimesylate | PDR |
| Max dose for adults | 70.0 | mg/day | 70 | mg/day | PO, oral | Vyvanse | lisdexamfetamine dimesylate | PDR |
| Max dose for geriatric | 70.0 | mg/day | 70 | mg/day | PO, oral | Vyvanse | lisdexamfetamine dimesylate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1