Basic Information
| Drug ID | DDPD01254 |
|
| Drug Name | Dasatinib | |
| Molecular Weight | 488.006 | |
| Molecular Formula | C22H26ClN7O2S | |
| CAS Number | 302962-49-8 | |
| SMILES | CC1=NC(NC2=NC=C(S2)C(=O)NC2=C(C)C=CC=C2Cl)=CC(=N1)N1CCN(CCO)CC1 | |
| External Links | ||
| DRUGBANK | DB01254 | |
| PubChem Compound | 3062316 | |
| PDR | 115 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.8 | - | 1.8 | - | DRUGBANK |
| Melting Point | 283.0 | ℃ | 280-286 | ℃ | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Volume of Distribution | 2505.0 | L | 2505.0 | L | DRUGBANK | |
| Half-life | 4.0 | h | 3-5 | h | terminal half-life; | DRUGBANK |
| Protein Binding | 96.0 | % | 96 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 40.0 | mg/day | 40 | mg/day | PO, oral | Sprycel | dasatinib | PDR |
| Max dose for children | 50.0 | mg/day | 50 | mg/day | PO, oral | Sprycel | dasatinib | PDR |
| Max dose for children | 60.0 | mg/day | 60 | mg/day | PO, oral | Sprycel | dasatinib | PDR |
| Max dose for children | 70.0 | mg/day | 70 | mg/day | PO, oral | Sprycel | dasatinib | PDR |
| Max dose for children | 70.0 | mg/day | 70 | mg/day | PO, oral | Sprycel | dasatinib | PDR |
| Max dose for children | 90.0 | mg/day | 90 | mg/day | PO, oral | Sprycel | dasatinib | PDR |
| Max dose for children | 100.0 | mg/day | 100 | mg/day | PO, oral | Sprycel | dasatinib | PDR |
| Max dose for children | 120.0 | mg/day | 120 | mg/day | PO, oral | Sprycel | dasatinib | PDR |
| Max dose for adolescents | 70.0 | mg/day | 70 | mg/day | PO, oral | Sprycel | dasatinib | PDR |
| Max dose for adolescents | 90.0 | mg/day | 90 | mg/day | PO, oral | Sprycel | dasatinib | PDR |
| Max dose for adolescents | 100.0 | mg/day | 100 | mg/day | PO, oral | Sprycel | dasatinib | PDR |
| Max dose for adolescents | 120.0 | mg/day | 120 | mg/day | PO, oral | Sprycel | dasatinib | PDR |
| Max dose for adults | 140.0 | mg/day | 140 | mg/day | PO, oral | Sprycel | dasatinib | PDR |
| Max dose for adults | 180.0 | mg/day | 180 | mg/day | PO, oral | Sprycel | dasatinib | PDR |
| Max dose for geriatric | 140.0 | mg/day | 140 | mg/day | PO, oral | Sprycel | dasatinib | PDR |
| Max dose for geriatric | 180.0 | mg/day | 180 | mg/day | PO, oral | Sprycel | dasatinib | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1