Basic Information
| Drug ID | DDPD01250 |
|
| Drug Name | Olsalazine | |
| Molecular Weight | 302.239 | |
| Molecular Formula | C14H10N2O6 | |
| CAS Number | 15722-48-2 | |
| SMILES | OC(=O)C1=CC(=CC=C1O)\N=N\C1=CC=C(O)C(=C1)C(O)=O | |
| External Links | ||
| DRUGBANK | DB01250 | |
| PubChem Compound | 6003770 | |
| PDR | 1932 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Caco-2 Permeability | -6.96 | - | -6.96 | - | ADME Research, USCD |
| Log P | 2.3 | - | 2.3 | - | DRUGBANK |
| Melting Point | 240.0 | ℃ | 240 | ℃ | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Metabolic | 98.5 | % | 98-99 | % | DRUGBANK | |
| Clearance | 0.0720 | L/h/kg | 1.2 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.0700 | L/kg | 0.07 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 0.90 | h | 0.9 | h | elimination half-life; | DRUGBANK | Half-life | 168.0 | h | 7 | day | Raceme L; | DRUGBANK | Half-life | 0.90 | h | 0.9 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 99.0 | % | >99 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 1000.0 | mg/day | 1 | g/day | PO, oral | Dipentum | olsalazine sodium | PDR |
| Max dose for geriatric | 1000.0 | mg/day | 1 | g/day | PO, oral | Dipentum | olsalazine sodium | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1