Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01241 ...
Drug Name Gemfibrozil
Molecular Weight 250.3334
Molecular Formula C15H22O3
CAS Number 25812-30-0
SMILES CC1=CC(OCCCC(C)(C)C(O)=O)=C(C)C=C1
External Links
DRUGBANK DB01241
T3DB T3D4809
PubChem Compound 3463
PDR 983
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 4.387 - 4.387 - ChemSpider
Boiling Point 158.5 ℃ 158.5 ℃ PhysProp
Melting Point 59.5 ℃ 58-61 ℃ FDA Label

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 98.0 % 98±1 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 46000.0 ng/ml 46±16 ug/ml PO, oral; normal,healthy; DRUGBANK
C Max 13800.0 ng/ml 13.8±11.1 ug/ml PO, oral; DRUGBANK
C Max 23000.0 ng/ml 23.0±10.3 ug/ml PO, oral; hepatopathy，LD; DRUGBANK
C Max 20000.0 ng/ml 15-25 mcg/ml PO, oral; The Pharmacological Basis of Therapeutics
T Max 2.2 h 2.2±1.1 h PO, oral; normal,healthy; DRUGBANK
T Max 2.3 h 2.3±1.0 h PO, oral; DRUGBANK
T Max 2.6 h 2.6±1.7 h PO, oral; hepatopathy，LD; DRUGBANK
T Max 1.5 h 1-2 h PO, oral; The Pharmacological Basis of Therapeutics
Clearance 6.0 L/h 6.0 L/h DRUGBANK
Clearance 0.10 L/h/kg 1.7±0.4 ml/min/kg Hepatic cirrhosis, cirr → ;RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.80 L/kg 0.8 L/kg DRUGBANK
Volume of Distribution 0.14 L/kg 0.14±0.03 L/kg The Pharmacological Basis of Therapeutics
Half-life 1.5 h 1.5 h elimination half-life; DRUGBANK
Half-life 2.4 h 2.4 h patients; DRUGBANK
Half-life 2.1 h 2.1 h RD, renal impairment, Renal disease，including uremia; patients; DRUGBANK
Half-life 1.1 h 1.1±0.2 h RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Toxicity LD50 2218.0 mg/kg 2218.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 1414.0 mg/kg 1414.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 445.0 mg/kg 445.0 mg/kg Intraperitoneal, IP; Rattus, Rat; DRUGBANK
Toxicity LD50 3162.0 mg/kg 3162.0 mg/kg PO, oral; mouse; T3DB
Eliminate Route 70.0 % ~70 % Urinary excretion; DRUGBANK
Eliminate Route 6.0 % ~6 % Faeces excretion; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 99.0 % 99 % DRUGBANK
Protein Binding 98.6 % 98.6 % DRUGBANK
Protein Binding 0 % ~0 % DRUGBANK
Protein Binding 0.80 % 0.8 % serum albumin; DRUGBANK
Protein Binding 97.0 % 97 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 1200.0 mg/day 1200 mg/day PO, oral Lopid gemfibrozil PDR
Max dose for adults 1600.0 mg/day 1600 mg/day PO, oral Lopid gemfibrozil PDR
Max dose for elderly 1200.0 mg/day 1200 mg/day PO, oral Lopid gemfibrozil PDR
Max dose for elderly 1600.0 mg/day 1600 mg/day PO, oral Lopid gemfibrozil PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1