Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01235 ...
Drug Name Levodopa
Molecular Weight 197.1879
Molecular Formula C9H11NO4
CAS Number 59-92-7
SMILES N[C@@H](CC1=CC(O)=C(O)C=C1)C(O)=O
External Links
DRUGBANK DB01235
T3DB T3D3028
PubChem Compound 6047
PDR 24284
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 0.05 - 0.05 - https://www.chemeo.com/cid/46-030-7/Levodopa.pdf
Boiling Point 448.4 ℃ 448.4 ℃ ChemSpider
Melting Point 295.0 ℃ 295 ℃ MSDS
Water Solubility 5.0 mM 5 mM ChemSpider

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 41.0 % 41±16 % PO, oral; The Pharmacological Basis of Therapeutics
Bioavailability 86.0 % 86±19 % combination drug use; The Pharmacological Basis of Therapeutics
C Max 1700.0 ng/ml 1.7±0.8 mcg/ml combination drug use; young; The Pharmacological Basis of Therapeutics
C Max 1900.0 ng/ml 1.9±0.6 mcg/ml combination drug use; Elderly; The Pharmacological Basis of Therapeutics
T Max 0.50 h 0.5 h inhalation, IH; DRUGBANK
T Max 1.4 h 1.4±0.7 h combination drug use; young; The Pharmacological Basis of Therapeutics
T Max 1.4 h 1.4±0.7 h combination drug use; Elderly; The Pharmacological Basis of Therapeutics
Clearance 0.85 L/h/kg 14.2 ml/min/kg intravenous injection, IV; Geriatric; DRUGBANK
Clearance 1.4 L/h/kg 23.4 ml/min/kg intravenous injection, IV; young; DRUGBANK
Clearance 0.35 L/h/kg 5.8 ml/min/kg Drug combination; Geriatric; DRUGBANK
Clearance 0.56 L/h/kg 9.3 ml/min/kg Drug combination; young; DRUGBANK
Clearance 1.4 L/h/kg 23±4 ml/min/kg Elderly ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.54 L/h/kg 9±1 ml/min/kg Drug combination; Elderly ↓ ; The Pharmacological Basis of Therapeutics
Clearance 1.4 L/h/kg 23 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 168.0 L 168.0 L PO, oral; DRUGBANK
Volume of Distribution 1.7 L/kg 1.7±0.4 L/kg Elderly ↓ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.90 L/kg 0.9±0.2 L/kg Drug combination; Elderly ↓ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.7 L/kg 1.7 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.3 h 2.3 h inhalation, IH; DRUGBANK
Half-life 0.83 h 50 min PO, oral; DRUGBANK
Half-life 1.5 h 1.5 h Drug combination; DRUGBANK
Half-life 1.4 h 1.4±0.4 h Age → ; The Pharmacological Basis of Therapeutics
Half-life 1.5 h 1.5±0.3 h Drug combination; Age → ; The Pharmacological Basis of Therapeutics
Half-life 1.3 h 1.3 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 2363.0 mg/kg 2363.0 mg/kg PO, oral; mouse; T3DB
Toxicity LD50 609.0 mg/kg 609.0 mg/kg PO, oral; rabbit; T3DB
Toxicity LD50 1780.0 mg/kg 1780.0 mg/kg PO, oral; Rattus, Rat; T3DB
Eliminate Route 17.0 % 17 % Faeces excretion; PO, oral; DRUGBANK
Eliminate Route 0.28 % 0.28 % lung excretion; PO, oral; DRUGBANK
Eliminate Route 78.4 % 78.4 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 0 % ~0 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 8000.0 mg/day 8 g/day PO, oral Inbrija levodopa PDR
Max dose for adults 420.0 mg/day 420 mg/day inhalation, IH Inbrija levodopa PDR
Max dose for geriatric 8000.0 mg/day 8 g/day PO, oral Inbrija levodopa PDR
Max dose for geriatric 420.0 mg/day 420 mg/day inhalation, IH Inbrija levodopa PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1