Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01234 ...
Drug Name Dexamethasone
Molecular Weight 392.4611
Molecular Formula C22H29FO5
CAS Number 50-02-2
SMILES [H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
External Links
DRUGBANK DB01234
T3DB T3D4982
PubChem Compound 5743
PDR 1725
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Caco-2 Permeability -4.75 - -4.75 - ADME Research, USCD
Log P 1.83 - 1.83 - HANSCH,C ET AL. (1995)
Melting Point 262.0 ℃ 260-264 ℃ ChemSpider
Water Solubility 89.0 mg/L 89 mg/L YALKOWSKY,SH & DANNENFELSER,RM 1992)
Log S -3.64 - -3.64 - ADME Research, USCD

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 113.0 ng.h/ml 113±38 ng.h/ml IM,intramuscular injection; DRUGBANK
AUC 331.0 ng.h/ml 331±50 ng.h/ml PO, oral; DRUGBANK
Bioavailability 74.0 % 70-78 % PO, oral; DRUGBANK
C Max 34.6 ng/ml 34.6±6.0 ng/ml IM,intramuscular injection; DRUGBANK
C Max 13.9 ng/ml 13.9±6.8 ng/ml PO, oral; DRUGBANK
T Max 2.0 h 2.0±1.2 h IM,intramuscular injection; DRUGBANK
T Max 2.0 h 2.0±0.5 h PO, oral; DRUGBANK
Clearance 15.7 L/h 15.7 L/h Tablet, PO, oral; DRUGBANK
Clearance 15.6 L/h 15.6±4.9 L/h PO, oral; DRUGBANK
Clearance 9.9 L/h 9.9±1.4 L/h IM,intramuscular injection; DRUGBANK
Clearance 0.20 L/h/kg 3.3 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 51.0 L 51.0 L PO, oral; DRUGBANK
Volume of Distribution 96.0 L 96.0 L IM,intramuscular injection; DRUGBANK
Volume of Distribution 0.94 L/kg 0.94 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 4.0 h 4 h terminal half-life; Tablet, PO, oral; DRUGBANK
Half-life 6.6 h 6.6±4.3 h PO, oral; DRUGBANK
Half-life 4.2 h 4.2±1.2 h IM,intramuscular injection; DRUGBANK
Half-life 3.7 h 3.7 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 6500.0 mg/kg 6.5 g/kg PO, oral; female mouse; DRUGBANK
Toxicity LD50 794.0 mg/kg 794.0 mg/kg intravenous injection, IV; female mouse; DRUGBANK
Toxicity LD50 3000.0 mg/kg >3 g/kg PO, oral; Rattus, Rat; T3DB
Protein Binding 77.0 % ~77 % plasma proteins; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1