Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01229 ...
Drug Name Paclitaxel
Molecular Weight 853.9061
Molecular Formula C47H51NO14
CAS Number 33069-62-4
SMILES [H][C@]12[C@H](OC(=O)C3=CC=CC=C3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)C4=CC=CC=C4)C4=CC=CC=C4)C(C)=C([C@@H](OC(C)=O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C
External Links
DRUGBANK DB01229
T3DB T3D4019
PubChem Compound 36314
PDR 1299
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.0 - 3.0 - DRUGBANK
Melting Point 216.5 ℃ 216-217 ℃ FDA label

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 6300.0 ng.h/ml 6300.0 ng.h/ml intravenous infusion, IV in drop; DRUGBANK
C Max 195.0 ng/ml 195 ng/ml intravenous infusion, IV in drop; DRUGBANK
C Max 725820.2 ng/ml 0.85±0.21 mM intravenous infusion, IV in drop; adults; tumor; The Pharmacological Basis of Therapeutics
Clearance 21.7 L/h/m2 21.7 L/h/m2 intravenous infusion, IV in drop; DRUGBANK
Clearance 23.8 L/h/m2 23.8 L/h/m2 intravenous infusion, IV in drop; DRUGBANK
Clearance 7.0 L/h/m2 7.0 L/h/m2 intravenous infusion, IV in drop; DRUGBANK
Clearance 12.2 L/h/m2 12.2 L/h/m2 intravenous infusion, IV in drop; DRUGBANK
Clearance 0.33 L/h/kg 5.5±3.5 ml/min/kg hydrolysis; hydrolysis; Children → ; The Pharmacological Basis of Therapeutics
Clearance 0.38 L/h/kg 6.4 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 457.5 L/m2 227-688 L/m2 at steady state; intravenous infusion, IV in drop; DRUGBANK
Volume of Distribution 2.0 L/kg 2.0±1.2 L/kg Children → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 3.0 L/kg 3 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 52.7 h 52.7 h ovarian cancer; DRUGBANK
Half-life 3.0 h 3±1 h The Pharmacological Basis of Therapeutics
Half-life 30.0 h 30 h terminal half-life; The Pharmacological Basis of Therapeutics
Half-life 11.0 h 11 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 32.5 mg/kg 32530.0 ug/kg Intraperitoneal, IP; Rattus, Rat; DRUGBANK
Toxicity LD50 32.5 mg/kg 32530.0 ug/kg Intraperitoneal, IP; Rattus, Rat; T3DB
Eliminate Route 71.0 % 71 % Faeces excretion; patients; human, homo sapiens; DRUGBANK
Eliminate Route 14.0 % 14 % Urinary excretion; patients; human, homo sapiens; DRUGBANK
Eliminate Route 5.0 % 5±2 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 93.5 % 89-98 % plasma proteins; DRUGBANK
Protein Binding 93.0 % 88-98 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 260.0 mg/m2 260 mg/m2 intravenous injection, IV Abraxane paclitaxel protein-bound PDR
Max dose for geriatric 260.0 mg/m2 260 mg/m2 intravenous injection, IV Abraxane paclitaxel protein-bound PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1