| Property Name |
Property Value |
Unit |
Raw Value |
Raw Unit |
Annotation |
Factor |
Reference |
| AUC |
5094.0 |
ng.h/ml |
5094.0 |
ng.h/ml |
PO, oral; extended release formulation; |
|
DRUGBANK |
| Bioavailability |
100.0 |
% |
100 |
% |
Tablet, PO, oral; |
|
DRUGBANK |
Bioavailability |
9.0 |
% |
9.0 |
% |
PO, oral; |
|
The Pharmacological Basis of Therapeutics |
| C Max |
467.0 |
ng/ml |
467 |
ng/ml |
PO, oral; extended release formulation; |
|
DRUGBANK |
C Max |
278.0 |
ng/ml |
278.0 |
ng/ml |
PO, oral; schizophrenia; |
|
The Pharmacological Basis of Therapeutics |
| T Max |
1.5 |
h |
1.5 |
h |
PO, oral; |
|
DRUGBANK |
T Max |
1.4 |
h |
1-1.8 |
h |
|
|
The Pharmacological Basis of Therapeutics |
| Tss |
48.0 |
h |
48 |
h |
PO, oral; |
|
DRUGBANK |
| Clearance |
101.0 |
L/h |
101.04±39.11 |
L/h |
normal,healthy; fasting; |
Geriatric ↓ ; |
DRUGBANK |
Clearance |
1.1 |
L/h/kg |
19.0 |
ml/min/kg |
|
Elderly ↓ ;hepatopathy，LD ↓ ;RD, renal impairment, Renal disease，including uremia → ; |
The Pharmacological Basis of Therapeutics |
| Volume of Distribution |
10.0 |
L/kg |
10±4 |
L/kg |
Apparent volume of distribution; |
|
DRUGBANK |
Volume of Distribution |
10.0 |
L/kg |
10±4 |
L/kg |
|
|
The Pharmacological Basis of Therapeutics |
| Half-life |
6.5 |
h |
~6-7 |
h |
terminal half-life; |
|
DRUGBANK |
Half-life |
6.0 |
h |
6.0 |
h |
|
|
The Pharmacological Basis of Therapeutics |
| Toxicity LD50 |
2000.0 |
mg/kg |
2000.0 |
mg/kg |
PO, oral; Rattus, Rat; |
|
DRUGBANK |
| Eliminate Route |
73.0 |
% |
~73 |
% |
Urinary excretion; |
|
DRUGBANK |
Eliminate Route |
20.0 |
% |
~20 |
% |
Faeces excretion; |
|
DRUGBANK |
Eliminate Route |
1.0 |
% |
<1 |
% |
Urinary excretion; PO, oral; Unchanged drug; |
|
DRUGBANK |
Eliminate Route |
1.0 |
% |
<1 |
% |
Urinary excretion; Unchanged drug; |
|
The Pharmacological Basis of Therapeutics |
| Protein Binding |
83.0 |
% |
83 |
% |
|
|
DRUGBANK |
Protein Binding |
83.0 |
% |
83 |
% |
|
|
The Pharmacological Basis of Therapeutics |
