Basic Information
| Drug ID | DDPD01223 |
|
| Drug Name | Aminophylline | |
| Molecular Weight | 420.4264 | |
| Molecular Formula | C16H24N10O4 | |
| CAS Number | 317-34-0 | |
| SMILES | NCCN.CN1C2=C(NC=N2)C(=O)N(C)C1=O.CN1C2=C(NC=N2)C(=O)N(C)C1=O | |
| External Links | ||
| DRUGBANK | DB01223 | |
| PubChem Compound | 9433 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -3.03 | - | -3.03 | - | DRUGBANK |
| Water Solubility | 200000.0 | mg/L | 200000 | mg/L | MERCK INDEX 1996) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 0.0279 | L/h/kg | 0.29-0.64 | ml/kg/min | postnatal; | DRUGBANK | Clearance | 0.0990 | L/h/kg | 1.6-1.7 | ml/kg/min | Children; | DRUGBANK | Clearance | 0.0690 | L/h/kg | 0.9-1.4 | ml/kg/min | Adolescents; | DRUGBANK | Clearance | 0.0390 | L/h/kg | 0.65 | ml/kg/min | adults; asthma; | DRUGBANK | Clearance | 0.0246 | L/h/kg | 0.41 | ml/kg/min | Elderly; | DRUGBANK | Clearance | 0.0198 | L/h/kg | 0.33 | ml/kg/min | Acute pulmonary edema; | DRUGBANK | Clearance | 0.0324 | L/h/kg | 0.54 | ml/kg/min | COPD, Chronic obstructive pulmonary disease; | DRUGBANK | Clearance | 0.0288 | L/h/kg | 0.48 | ml/kg/min | COPD, Chronic obstructive pulmonary disease; CP,cor pulmonale; | DRUGBANK | Clearance | 0.0750 | L/h/kg | 1.25 | ml/kg/min | Cystic fibrosis; | DRUGBANK | Clearance | 0.0186 | L/h/kg | 0.31 | ml/kg/min | cholestasis; | DRUGBANK | Clearance | 0.0300 | L/h/kg | 0.35-0.65 | ml/kg/min | Hepatitis, Hep; | DRUGBANK | Clearance | 0.0282 | L/h/kg | 0.47 | ml/kg/min | Sepsis; multi-organ failure; | DRUGBANK | Clearance | 0.0228 | L/h/kg | 0.38 | ml/kg/min | LTh hypothyroid; | DRUGBANK | Clearance | 0.0480 | L/h/kg | 0.8 | ml/kg/min | hyperthyroid, HTh; | DRUGBANK |
| Volume of Distribution | 0.50 | L/kg | 0.3-0.7 | L/kg | DRUGBANK | |
| Half-life | 8.0 | h | 7-9 | h | DRUGBANK | |
| Protein Binding | 60.0 | % | 60 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1