Basic Information

Drug ID DDPD01221 ...
Drug Name Ketamine
Molecular Weight 237.725
Molecular Formula C13H16ClNO
CAS Number 6740-88-1
SMILES CNC1(CCCCC1=O)C1=CC=CC=C1Cl
External Links
DRUGBANK DB01221
T3DB T3D3025
PubChem Compound 3821
PDR 1999
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.12 - 3.12 - Medical toxicology of drug abuse. (2012)
Melting Point 92.5 92.5 Medical toxicology of drug abuse. (2012)
pKa 7.5 - 7.5 - Ketamine monograph

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 93.0 % 93 % DRUGBANK
C Max 750.0 ng/ml 0.75 mcg/ml DRUGBANK
Clearance 1.4 L/h/kg 95.0 L/h/70kg DRUGBANK
Clearance 1.1 L/h/kg 19 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.37 L/kg 371.3 ml/kg Total volume of distribution; DRUGBANK
Volume of Distribution 4.1 L/kg 4060.3 ml/kg at steady state; DRUGBANK
Volume of Distribution 2.9 L/kg 2.9 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 3.1 h 186 min DRUGBANK
Half-life 2.8 h 2.8 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 91.0 % 91 % Urinary excretion; intravenous injection, IV; DRUGBANK
Eliminate Route 3.0 % 3 % Faeces excretion; intravenous injection, IV; DRUGBANK
Protein Binding 53.5 % 53.5 % plasma proteins; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1