Basic Information
| Drug ID | DDPD01220 |
|
| Drug Name | Rifaximin | |
| Molecular Weight | 785.8785 | |
| Molecular Formula | C43H51N3O11 | |
| CAS Number | 80621-81-4 | |
| SMILES | CO[C@H]1\C=C\O[C@@]2(C)OC3=C(C)C(O)=C4C(O)=C(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C1=C(N=C5C=C(C)C=CN15)C4=C3C2=O | |
| External Links | ||
| DRUGBANK | DB01220 | |
| PubChem Compound | 6436173 | |
| PDR | 502 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.6 | - | 2.6 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Half-life | 6.0 | h | ~6 | h | DRUGBANK | |
| Toxicity LD50 | 2000.0 | mg/kg | >2 | g/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Eliminate Route | 96.6 | % | 96.62 | % | Faeces excretion; PO, oral; normal,healthy; human, homo sapiens; | DRUGBANK | Eliminate Route | 0.32 | % | 0.32 | % | Urinary excretion; PO, oral; normal,healthy; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 600.0 | mg/day | 600 | mg/day | PO, oral | Xifaxan | rifaximin | PDR |
| Max dose for adolescents | 600.0 | mg/day | 600 | mg/day | PO, oral | Xifaxan | rifaximin | PDR |
| Max dose for adults | 600.0 | mg/day | 600 | mg/day | PO, oral | Xifaxan | rifaximin | PDR |
| Max dose for adults | 1100.0 | mg/day | 1100 | mg/day | PO, oral | Xifaxan | rifaximin | PDR |
| Max dose for adults | 1650.0 | mg/day | 1650 | mg/day | Xifaxan | rifaximin | PDR | |
| Max dose for geriatric | 600.0 | mg/day | 600 | mg/day | PO, oral | Xifaxan | rifaximin | PDR |
| Max dose for geriatric | 1100.0 | mg/day | 1100 | mg/day | PO, oral | Xifaxan | rifaximin | PDR |
| Max dose for geriatric | 1650.0 | mg/day | 1650 | mg/day | Xifaxan | rifaximin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1