Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01217 ...
Drug Name Anastrozole
Molecular Weight 293.3663
Molecular Formula C17H19N5
CAS Number 120511-73-1
SMILES CC(C)(C#N)C1=CC(=CC(CN2C=NC=N2)=C1)C(C)(C)C#N
External Links
DRUGBANK DB01217
T3DB T3D4796
PubChem Compound 2187
PDR 1717
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.58 - 1.58 - Canadian label (DPD)
Water Solubility 530.0 mg/L 0.53 mg/ml Canadian label DPD)
pKa 1.4 - 1.4 - Canadian label (DPD)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 80.0 % 80.0 % PO, oral; postmenopausal women;  Female, women; The Pharmacological Basis of Therapeutics
C Max 46.0 ng/ml 46.0 ng/ml Oral single dose; postmenopausal women;  Female, women; The Pharmacological Basis of Therapeutics
T Max 2.0 h 2 h PO, oral; fasting; DRUGBANK
T Max 2.0 h ≤2 h Oral single dose; postmenopausal women;  Female, women; The Pharmacological Basis of Therapeutics
Volume of Distribution 3.2 L 3.19 mL/g mouse; DRUGBANK
Half-life 50.0 h ~50 h elimination half-life; DRUGBANK
Half-life 50.0 h 50.0 h normal,healthy; postmenopausal women; Asian; The Pharmacological Basis of Therapeutics
Toxicity TDLo 1.7 mg/kg 1.68 mg/kg PO, oral; human, homo sapiens;  Female, women; DRUGBANK
Eliminate Route 85.0 % 85 % lung excretion; DRUGBANK
Eliminate Route 10.0 % ~10 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 10.0 % <10 % Urinary excretion; postmenopausal women;  Female, women; normal,healthy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 40.0 % 40 % Plasma Concentration → ; DRUGBANK
Protein Binding 40.0 % ~40 % postmenopausal women;  Female, women; normal,healthy; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for adults 1.0 mg 1 mg PO, oral qd Arimidex anastrozole PDR
Max dose for geriatric 1.0 mg 1 mg PO, oral qd Arimidex anastrozole PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1