Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01216 ...
Drug Name Finasteride
Molecular Weight 372.5441
Molecular Formula C23H36N2O2
CAS Number 98319-26-7
SMILES [H][C@@]12CC[C@H](C(=O)NC(C)(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])NC(=O)C=C[C@]12C
External Links
DRUGBANK DB01216
T3DB T3D4820
PubChem Compound 57363
PDR 378
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.03 - 3.03 - HANSCH,C ET AL. (1995)
Melting Point 253.0 ℃ 252-254 ℃ MSDS

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 53.0 ng.h/ml 53(20-154) ng.h/ml PO, oral; DRUGBANK
Bioavailability 65.0 % 65(26-170) % PO, oral; normal,healthy; Male, men; DRUGBANK
Bioavailability 63.0 % 63(34-108) % PO, oral; normal,healthy; Male, men; DRUGBANK
Bioavailability 63.0 % 63±21 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 37.0 ng/ml 37(27-49) ng/ml PO, oral; DRUGBANK
C Max 37.0 ng/ml 37(27-49) ng/ml Oral single dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.5 h 1-2 h PO, oral; DRUGBANK
T Max 1.5 h 1-2 h Oral single dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 9.9 L/h 165.0 ml/min Plasma clearance; normal,healthy; young; DRUGBANK
Clearance 0.14 L/h/kg 2.3±0.8 ml/min/kg normal,healthy; adults; Elderly → ;RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Clearance 0.14 L/h/kg 2.4 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 76.0 L 76.0 L at steady state; DRUGBANK
Volume of Distribution 1.1 L/kg 1.1±0.2 L/kg normal,healthy; adults; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.1 L/kg 1.1 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 5.0 h 5(3-16) h elimination half-life; normal,healthy; young; DRUGBANK
Half-life 8.0 h 8 h Elderly; DRUGBANK
Half-life 7.9 h 7.9±2.5 h RD, renal impairment, Renal disease，including uremia → ;Age → ; The Pharmacological Basis of Therapeutics
Half-life 6.0 h 6 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 418.0 mg/kg ~418 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity Lethal Dose 400.0 mg/kg 400.0 mg/kg Oral single dose; male rat; DRUGBANK
Toxicity Lethal Dose 1000.0 mg/kg 1000.0 mg/kg Oral single dose; female rat; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 90.0 % ~90 % plasma proteins; DRUGBANK
Protein Binding 90.0 % 90 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 5.0 mg/day 5 mg/day PO, oral Propecia finasteride PDR
Max dose for adults 80.0 mg/day 80 mg/day PO, oral Propecia finasteride PDR
Max dose for adults 1.0 mg/day 1 mg/day PO, oral Propecia finasteride PDR
Max dose for elderly 5.0 mg/day 5 mg/day PO, oral Propecia finasteride PDR
Max dose for elderly 80.0 mg/day 80 mg/day PO, oral Propecia finasteride PDR
Max dose for elderly 1.0 mg/day 1 mg/day PO, oral Propecia finasteride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1