Basic Information
| Drug ID | DDPD01212 |
|
| Drug Name | Ceftriaxone | |
| Molecular Weight | 554.58 | |
| Molecular Formula | C18H18N8O7S3 | |
| CAS Number | 73384-59-5 | |
| SMILES | [H][C@]12SCC(CSC3=NC(=O)C(=O)NN3C)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\C1=CSC(N)=N1)C(O)=O | |
| External Links | ||
| DRUGBANK | DB01212 | |
| T3DB | T3D2568 | |
| PubChem Compound | 5479530 | |
| PDR | 1723 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Caco-2 Permeability | -6.88 | - | -6.88 | - | ADME Research, USCD |
| Log P | -1.7 | - | -1.7 | - | DRUGBANK |
| Melting Point | 155.0 | ℃ | >155 | ℃ | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 1.0 | L/h | 0.58-1.45 | L/h | normal,healthy; adults; | DRUGBANK | Clearance | 0.0132 | L/h/kg | 0.22 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 9.6 | L | 5.78-13.5 | L | DRUGBANK | Volume of Distribution | 0.12 | L/kg | 0.12 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 7.3 | h | 5.8-8.7 | h | DRUGBANK | Half-life | 7.6 | h | 7.6 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 10000.0 | mg/kg | >10 000 | mg/kg | PO, oral; Rattus, Rat; | T3DB |
| Eliminate Route | 50.0 | % | 33-67 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 95.0 | % | 95 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 100.0 | mg/kg/day | 100 | mg/kg/day | intravenous injection, IV | Ceftriaxone | ceftriaxone | PDR |
| Max dose for neonates | 50.0 | mg/kg/day | 50 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Ceftriaxone | ceftriaxone | PDR |
| Max dose for infants | 100.0 | mg/kg/day | 100 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Ceftriaxone | ceftriaxone | PDR |
| Max dose for children | 100.0 | mg/kg/day | 100 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Ceftriaxone | ceftriaxone | PDR |
| Max dose for children | 4000.0 | mg/day | 4 | g/day | intravenous injection, IV;IM,intramuscular injection; | Ceftriaxone | ceftriaxone | PDR |
| Max dose for adolescents | 100.0 | mg/kg/day | 100 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Ceftriaxone | ceftriaxone | PDR |
| Max dose for adolescents | 4000.0 | mg/day | 4 | g/day | intravenous injection, IV;IM,intramuscular injection; | Ceftriaxone | ceftriaxone | PDR |
| Max dose for adults | 4000.0 | mg/day | 4 | g/day | intravenous injection, IV;IM,intramuscular injection; | Ceftriaxone | ceftriaxone | PDR |
| Max dose for geriatric | 4000.0 | mg/day | 4 | g/day | intravenous injection, IV;IM,intramuscular injection; | Ceftriaxone | ceftriaxone | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1