DETAILS

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Log P	2.83	-	2.83	-	HANSCH,C & LEO,AJ (1985)
Melting Point	89.0	℃	88-90	℃	PhysProp
Water Solubility	111.0	mg/L	111	mg/L	DRUGBANK

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Reference
Half-life	1.6	h	~94	min		DRUGBANK
Half-life	32.0	h	16-48	h	elimination half-life; Metabolite;	DRUGBANK
Toxicity LD50	70.0	mg/kg	70.0	mg/kg	PO, oral; Rattus, Rat;	DRUGBANK
Toxicity LD50	70.0	mg/kg	70.0	mg/kg	PO, oral; Rattus, Rat;	T3DB
Eliminate Route	50.0	%	~50	%	Urinary excretion; PO, oral;	DRUGBANK
Protein Binding	50.0	%	50	%		DRUGBANK

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Frequency	Brand Name	Component	Reference
Max dose for infants	130.0	mg/m2	130	mg/m2	PO, oral; nan	q6w	Gleostine	lomustine	PDR
Max dose for children	130.0	mg/m2	130	mg/m2	PO, oral; nan	q6w	Gleostine	lomustine	PDR
Max dose for adolescents	130.0	mg/m2	130	mg/m2	PO, oral; nan	q6w	Gleostine	lomustine	PDR
Max dose for adults	130.0	mg/m2	130	mg/m2	PO, oral	q6wk	Gleostine	lomustine	PDR
Max dose for adults	200.0	mg/m2	200	mg/m2	PO, oral		Gleostine	lomustine	PDR
Max dose for geriatric	130.0	mg/m2	130	mg/m2	PO, oral; nan	q6w	Gleostine	lomustine	PDR
Max dose for geriatric	200.0	mg/m2	200	mg/m2	PO, oral		Gleostine	lomustine	PDR

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1