Basic Information
| Drug ID | DDPD01205 |
|
| Drug Name | Flumazenil | |
| Molecular Weight | 303.2884 | |
| Molecular Formula | C15H14FN3O3 | |
| CAS Number | 78755-81-4 | |
| SMILES | CCOC(=O)C1=C2CN(C)C(=O)C3=C(C=CC(F)=C3)N2C=N1 | |
| External Links | ||
| DRUGBANK | DB01205 | |
| PubChem Compound | 3373 | |
| PDR | 1729 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.0 | - | 1.0 | - | MFG DATA SHEET |
| Melting Point | 202.0 | ℃ | 201-203 | ℃ | PhysProp |
| Water Solubility | 128.0 | mg/L | 128 | mg/L | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Bioavailability | 16.0 | % | 16.0 | % | PO, oral; | The Pharmacological Basis of Therapeutics | |
| C Max | 15.0 | ng/ml | 10-20 | ng/ml | intravenous injection, IV; | The Pharmacological Basis of Therapeutics | |
| Metabolic | 99.0 | % | 99 | % | Liver metabolism; | DRUGBANK | |
| Clearance | 1.0 | L/h/kg | 1.0 | l/h/kg | intravenous infusion, IV in drop; normal,healthy; | DRUGBANK | Clearance | 0.59 | L/h/kg | 9.9±3.1 | ml/min/kg | moderate hepatic impairment ↓ ;severe hepatic impairment ↓ ; | The Pharmacological Basis of Therapeutics | Clearance | 0.96 | L/h/kg | 16 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.0 | L/kg | 0.9-1.1 | L/kg | DRUGBANK | Volume of Distribution | 0.63 | L/kg | 0.63±0.18 | L/kg | The Pharmacological Basis of Therapeutics | Volume of Distribution | 0.80 | L/kg | 0.8 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 0.13 | h | 4-11 | min | distribution half-life; | DRUGBANK | Half-life | 1.0 | h | 40-80 | min | terminal half-life; | DRUGBANK | Half-life | 1.3 | h | 1.3 | h | moderate hepatic impairment; | DRUGBANK | Half-life | 2.4 | h | 2.4 | h | severe hepatic impairment; | DRUGBANK | Half-life | 0.67 | h | 40(20-75) | min | pediatric patients; | DRUGBANK | Half-life | 0.90 | h | 0.9±0.2 | h | moderate hepatic impairment ↑ ;severe hepatic impairment ↑ ; | The Pharmacological Basis of Therapeutics | Half-life | 0.78 | h | 0.78 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 92.5 | % | 90-95 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 7.5 | % | 5-10 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 0.20 | % | <0.2 | % | Urinary excretion; Unchanged drug; | The Pharmacological Basis of Therapeutics |
| Protein Binding | 50.0 | % | ~50 | % | Hepatitis, Hep ↓ ; | DRUGBANK | Protein Binding | 33.0 | % | 33 | % | DRUGBANK | Protein Binding | 40.0 | % | 40(36-46) | % | The Pharmacological Basis of Therapeutics |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 0.02 | mg/kg | 20 | mcg/kg | intravenous injection, IV | Flumazenil | flumazenil | PDR |
| Max dose for neonates | 0.05 | mg/kg | 50 | mcg/kg | intravenous injection, IV | Flumazenil | flumazenil | PDR |
| Max dose for neonates | 0.48 | mg/kg/day | 20 | mcg/kg/hour | intravenous infusion, iv in drop | Flumazenil | flumazenil | PDR |
| Max dose for infants | 0.03 | mg/kg | 30 | mcg/kg | intravenous injection, IV | Flumazenil | flumazenil | PDR |
| Max dose for infants | 0.2 | mg/dose | 200 | mcg/dose | intravenous injection, IV | Flumazenil | flumazenil | PDR |
| Max dose for infants | 0.05 | mg/kg | 50 | mcg/kg | intravenous injection, IV | Flumazenil | flumazenil | PDR |
| Max dose for infants | 1.0 | mg | 1 | mg | intravenous injection, IV | Flumazenil | flumazenil | PDR |
| Max dose for infants | 0.24 | mg/kg/day | 10 | mcg/kg/h | intravenous infusion, iv in drop | Flumazenil | flumazenil | PDR |
| Max dose for children | 0.01 | mg/kg | 10 | mcg/kg | intravenous injection, IV | Flumazenil | flumazenil | PDR |
| Max dose for children | 0.2 | mg/dose | 200 | mcg/dose | intravenous injection, IV | Flumazenil | flumazenil | PDR |
| Max dose for children | 0.05 | mg/kg | 50 | mcg/kg | intravenous injection, IV | Flumazenil | flumazenil | PDR |
| Max dose for children | 1.0 | mg | 1 | mg | intravenous injection, IV | Flumazenil | flumazenil | PDR |
| Max dose for children | 0.24 | mg/kg/day | 10 | mcg/kg/hour | intravenous infusion, iv in drop | Flumazenil | flumazenil | PDR |
| Max dose for adolescents | 0.01 | mg/day | 10 | mcg/kg | intravenous injection, IV | Flumazenil | flumazenil | PDR |
| Max dose for adolescents | 0.2 | mg/dose | 200 | mcg/dose | intravenous injection, IV | Flumazenil | flumazenil | PDR |
| Max dose for adolescents | 0.05 | mg/day | 50 | mcg/kg | intravenous injection, IV | Flumazenil | flumazenil | PDR |
| Max dose for adolescents | 1.0 | mg | 1 | mg | intravenous injection, IV | Flumazenil | flumazenil | PDR |
| Max dose for adolescents | 0.01 | mg/kg/day | 10 | mcg/kg/hour | intravenous infusion, iv in drop | Flumazenil | flumazenil | PDR |
| Max dose for adults | 5.0 | mg | 5 | mg | intravenous injection, IV | Flumazenil | flumazenil | PDR |
| Max dose for adults | 1.0 | mg | 1 | mg | intravenous injection, IV | Flumazenil | flumazenil | PDR |
| Max dose for geriatric | 5.0 | mg | 5 | mg | intravenous injection, IV | Flumazenil | flumazenil | PDR |
| Max dose for geriatric | 1.0 | mg | 1 | mg | intravenous injection, IV | Flumazenil | flumazenil | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1