Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01204 ...
Drug Name Mitoxantrone
Molecular Weight 444.4809
Molecular Formula C22H28N4O6
CAS Number 65271-80-9
SMILES OCCNCCNC1=CC=C(NCCNCCO)C2=C1C(=O)C1=C(C(O)=CC=C1O)C2=O
External Links
DRUGBANK DB01204
T3DB T3D3020
PubChem Compound 4212
PDR 2630
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -3.1 - -3.1 - DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
C Max 308.0 ng/ml 308±133 ng/ml The Pharmacological Basis of Therapeutics
Clearance 21.3 L/h/m2 21.3 L/h/m2 intravenous injection, IV; Geriatric; breast cancer; DRUGBANK
Clearance 28.3 L/h/m2 28.3 L/h/m2 intravenous injection, IV; pediatric patients; nasopharyngeal carcinoma; DRUGBANK
Clearance 16.2 L/h/m2 16.2 L/h/m2 intravenous injection, IV; pediatric patients; malignant lymphoma; DRUGBANK
Clearance 0.78 L/h/kg 13±8 ml/min/kg tumor; patients; RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.47 L/h/kg 7.9 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 1000.0 L/m2 1000.0 L/m2 DRUGBANK
Volume of Distribution 90.0 L/kg 90±42 L/kg tumor; patients; The Pharmacological Basis of Therapeutics
Volume of Distribution 12.0 L/kg 12 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 75.0 h 75 h DRUGBANK
Half-life 1.1 h 1.1±1.1 h tumor; patients; intravenous infusion, IV in drop; at steady state; chronic liver disease ↑ ; The Pharmacological Basis of Therapeutics
Half-life 72.0 h 72±40 h tumor; patients; intravenous infusion, IV in drop; at steady state; chronic liver disease ↑ ; The Pharmacological Basis of Therapeutics
Half-life 53.0 h 53 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 2.0 % ~2 % Urinary excretion; tumor; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 78.0 % 78 % DRUGBANK
Protein Binding 97.0 % 97 % tumor; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 140.0 mg/m2 140 mg/m2 intravenous injection, IV Mitoxantrone mitoxantrone PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1