Basic Information
| Drug ID | DDPD01202 |
|
| Drug Name | Levetiracetam | |
| Molecular Weight | 170.212 | |
| Molecular Formula | C8H14N2O2 | |
| CAS Number | 102767-28-2 | |
| SMILES | CC[C@H](N1CCCC1=O)C(N)=O | |
| External Links | ||
| DRUGBANK | DB01202 | |
| T3DB | T3D3019 | |
| PubChem Compound | 5284583 | |
| PDR | 1054 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -0.6 | - | -0.6 | - | DRUGBANK |
| Melting Point | 115.0 | ℃ | 115-119 | ℃ | Canadian label |
| Water Solubility | 1040000.0 | mg/L | 104 | g/100ml | Canadian label |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Absorption | 100.0 | % | ~100 | % | PO, oral; | DRUGBANK | |
| Bioavailability | 100.0 | % | ~100 | % | PO, oral; | DRUGBANK | Bioavailability | 100.0 | % | ~100 | % | PO, oral; adults; epilepsy; normal,healthy; | The Pharmacological Basis of Therapeutics |
| C Max | 31000.0 | ng/ml | 31 | ug/ml | Oral single dose; | DRUGBANK | C Max | 43000.0 | ng/ml | 43 | ug/ml | Oral multiple dose; | DRUGBANK | C Max | 24800.0 | ng/ml | 24.8 | ug/ml | Oral single dose; food; | food ↓ ; | DRUGBANK | C Max | 10000.0 | ng/ml | ~10 | mcg/ml | PO, oral; adults; normal,healthy; | The Pharmacological Basis of Therapeutics |
| T Max | 1.3 | h | 1.3 | h | Oral single dose; | DRUGBANK | T Max | 2.8 | h | 2.8 | h | Oral single dose; food; | food ↑ ; | DRUGBANK | T Max | 0.75 | h | 0.5-1.0 | h | PO, oral; adults; normal,healthy; | The Pharmacological Basis of Therapeutics |
| Metabolic | 24.0 | % | 24 | % | Inactive metabolite; | DRUGBANK | |
| Clearance | 0.0576 | L/h/kg | 0.96 | ml/min/kg | Plasma clearance; | DRUGBANK | Clearance | 0.0366 | L/h/kg | 0.6 | ml/min/kg | Renal clearance; | RD, renal impairment, Renal disease，including uremia ↓ ; | DRUGBANK | Clearance | 0.24 | L/h/kg | 4.0 | ml/min/kg | Renal clearance; | DRUGBANK | Clearance | 0.0576 | L/h/kg | 0.96 | ml/min/kg | Children ↑ ;Elderly ↓ ;severe hepatic impairment ↓ ;severe renal function ↓ ; | The Pharmacological Basis of Therapeutics | Clearance | 0.0540 | L/h/kg | 0.9 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.60 | L/kg | ~0.5-0.7 | L/kg | DRUGBANK | Volume of Distribution | 0.60 | L/kg | 0.5-0.7 | L/kg | The Pharmacological Basis of Therapeutics | Volume of Distribution | 0.60 | L/kg | 0.6 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 7.0 | h | 6-8 | h | elimination half-life; | dose → ; | DRUGBANK | Half-life | 7.0 | h | 7±1 | h | normal,healthy; adults; patients; epilepsy; | mild renal function ↑ ;Age ↑ ; | The Pharmacological Basis of Therapeutics | Half-life | 8.2 | h | 8.23 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity TDLo | 10.0 | mg/kg | 10.0 | mg/kg | PO, oral; human, homo sapiens; | DRUGBANK | |
| Eliminate Route | 0.30 | % | 0.3 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 66.0 | % | ~66 | % | Urinary excretion; Unchanged drug; | DRUGBANK | Eliminate Route | 60.0 | % | 66 | % | Urinary excretion; adults; normal,healthy; epilepsy; human, homo sapiens; Unchanged drug; | The Pharmacological Basis of Therapeutics |
| Protein Binding | 10.0 | % | <10 | % | plasma proteins; | DRUGBANK | Protein Binding | 10.0 | % | <10 | % | adults; normal,healthy; epilepsy; human, homo sapiens; | The Pharmacological Basis of Therapeutics |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 60.0 | mg/kg/day | 60 | mg/kg/day | PO, oral | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for neonates | 80.0 | mg/kg/day | 80 | mg/kg/day | intravenous injection, IV | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for infants | 50.0 | mg/kg/day | 50 | mg/kg/day | PO, oral;intravenous injection, IV; | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for infants | 60.0 | mg/kg/day | 60 | mg/kg/day | intravenous injection, IV | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for infants | 42.0 | mg/kg/day | 42 | mg/kg/day | PO, oral;intravenous injection, IV; | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for infants | 60.0 | mg/kg/day | 60 | mg/kg/day | intravenous injection, IV | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for children | 60.0 | mg/kg/day | 60 | mg/kg/day | Liquid;intravenous injection, IV; | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for children | 3000.0 | mg/day | 3000 | mg/day | intravenous injection, IV | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for children | 3000.0 | mg/day | 3000 | mg/day | Tablet,PO，oral | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for children | 60.0 | mg/kg | 60 | mg/kg | intravenous injection, IV | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for children | 4500.0 | mg | 4500 | mg | intravenous injection, IV | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for children | 60.0 | mg/kg/day | 60 | mg/kg/day | Liquid;intravenous injection, IV; | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for children | 1500.0 | mg/day | 1500 | mg/day | Tablet,PO，oral | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for children | 60.0 | mg/kg | 60 | mg/kg | intravenous injection, IV | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for children | 50.0 | mg/kg/day | 50 | mg/kg/day | Liquid;intravenous injection, IV; | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for children | 60.0 | mg/kg | 60 | mg/kg | intravenous injection, IV | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for adolescents | 3000.0 | mg/day | 3000 | mg/day | PO, oral;intravenous injection, IV; | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for adolescents | 60.0 | mg/kg | 60 | mg/kg | intravenous injection, IV | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for adolescents | 4500.0 | mg | 4500 | mg | intravenous injection, IV | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for adolescents | 60.0 | mg/kg/day | 60 | mg/kg/day | PO, oral;intravenous injection, IV; | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for adolescents | 3000.0 | mg/day | 3000 | mg/day | intravenous injection, IV | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for adolescents | 60.0 | mg/kg | 60 | mg/kg | intravenous injection, IV | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for adolescents | 4500.0 | mg | 4500 | mg | intravenous injection, IV | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for adults | 3000.0 | mg/day | 3000 | mg/day | PO, oral;intravenous injection, IV; | Keppra Oral Solution and Tablets | levetiracetam | PDR |
| Max dose for geriatric | 3000.0 | mg/day | 3000 | mg/day | PO, oral;intravenous injection, IV; | Keppra Oral Solution and Tablets | levetiracetam | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1