Basic Information
| Drug ID | DDPD01198 |
|
| Drug Name | Zopiclone | |
| Molecular Weight | 388.808 | |
| Molecular Formula | C17H17ClN6O3 | |
| CAS Number | 43200-80-2 | |
| SMILES | CN1CCN(CC1)C(=O)OC1N(C(=O)C2=NC=CN=C12)C1=NC=C(Cl)C=C1 | |
| External Links | ||
| DRUGBANK | DB01198 | |
| T3DB | T3D3016 | |
| PubChem Compound | 5735 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.8 | - | 0.8 | - | DRUGBANK |
| Melting Point | 178.0 | ℃ | 178 | ℃ | PhysProp |
| Water Solubility | 151.0 | mg/L | 0.151 | mg/ml | MEYLAN,WM et al. 1996) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Metabolic | 12.0 | % | 12 | % | Liver metabolism; Active metabolite; | DRUGBANK | Metabolic | 16.0 | % | 16 | % | Liver metabolism; Inactive metabolite; | DRUGBANK |
| Clearance | 0.20 | L/h/kg | 3.3 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.3 | L/kg | 1.3 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 5.0 | h | ~5(3.8-6.5) | h | elimination half-life; | DRUGBANK | Half-life | 11.9 | h | 11.9 | h | hepatic insufficiency; patients; | DRUGBANK | Half-life | 5.2 | h | 5.2 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 45.0 | % | ~45 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1