Basic Information
| Drug ID | DDPD01197 |
|
| Drug Name | Captopril | |
| Molecular Weight | 217.285 | |
| Molecular Formula | C9H15NO3S | |
| CAS Number | 62571-86-2 | |
| SMILES | C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O | |
| External Links | ||
| DRUGBANK | DB01197 | |
| PubChem Compound | 44093 | |
| PDR | 2348 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.34 | - | 0.34 | - | RANADIVE,SA ET AL. (1992) |
| Melting Point | 103.5 | ℃ | 103-104 | ℃ | Ondetti, M.A. and Cushman, D.W.; U.S. Patent 4,046,889; September 6, 1977; assigned t o E.R. Squibb & Sons, Inc. Ondetti, M.A. and Cushman, D.W.; U.S. Patent 4,105,776; August 8,1978; assigned to E.R. Squibb & Sons, Inc. Ondetti, M.A. and Cushman, D.W.; U.S. Patent 4,154,840; May 15,1979; assigned to E.R. Squibb & Sons, Inc. |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Absorption | 67.5 | % | 60-75 | % | PO, oral; | DRUGBANK | Absorption | 46.0 | % | 36-56 | % | PO, oral; food; | food ↓ ; | DRUGBANK |
| Clearance | 0.72 | L/h/kg | 12 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset | |
| Volume of Distribution | 0.75 | L/kg | 0.75 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset | |
| Half-life | 2.0 | h | 2 | h | DRUGBANK | Half-life | 2.0 | h | 2 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 27.5 | % | 25-30 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 6.0 | mg/kg/day | 6 | mg/kg/day | PO, oral | Captopril | captopril | PDR |
| Max dose for neonates | 1.5 | mg/kg/day | 1.5 | mg/kg/day | PO, oral | Captopril | captopril | PDR |
| Max dose for infants | 6.0 | mg/kg/day | 6 | mg/kg/day | PO, oral | Captopril | captopril | PDR |
| Max dose for infants | 1.5 | mg/kg/day | 1.5 | mg/kg/day | PO, oral | Captopril | captopril | PDR |
| Max dose for children | 6.0 | mg/kg/day | 6 | mg/kg/day | PO, oral | Captopril | captopril | PDR |
| Max dose for children | 450.0 | mg/day | 450 | mg/day | PO, oral | Captopril | captopril | PDR |
| Max dose for adolescents | 6.0 | mg/kg/day | 6 | mg/kg/day | PO, oral | Captopril | captopril | PDR |
| Max dose for adolescents | 450.0 | mg/day | 450 | mg/day | PO, oral | Captopril | captopril | PDR |
| Max dose for adults | 450.0 | mg/day | 450 | mg/day | PO, oral | Captopril | captopril | PDR |
| Max dose for geriatric | 450.0 | mg/day | 450 | mg/day | PO, oral | Captopril | captopril | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1