Basic Information
| Drug ID | DDPD01193 |
|
| Drug Name | Acebutolol | |
| Molecular Weight | 336.4259 | |
| Molecular Formula | C18H28N2O4 | |
| CAS Number | 37517-30-9 | |
| SMILES | CCCC(=O)NC1=CC=C(OCC(O)CNC(C)C)C(=C1)C(C)=O | |
| External Links | ||
| DRUGBANK | DB01193 | |
| PubChem Compound | 1978 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Caco-2 Permeability | -5.83 | - | -5.83 | - | ADME Research, USCD |
| Log P | 1.71 | - | 1.71 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 137.0 | ℃ | 136-138 | ℃ | Merck Index 13 |
| Water Solubility | 259.0 | mg/L | 259 | mg/L | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 40.0 | % | 40 | % | PO, oral; | DRUGBANK |
| Clearance | 0.60 | L/h/kg | 10 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.7 | L/kg | 1.7 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 3.5 | h | ~3-4 | h | elimination half-life; | DRUGBANK | Half-life | 10.5 | h | 8-13 | h | DRUGBANK | Half-life | 3.5 | h | 3.5 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 35.0 | % | ~30-40 | % | Urinary excretion; | DRUGBANK |
| Protein Binding | 26.0 | % | 26 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1