Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01183 ...
Drug Name Naloxone
Molecular Weight 327.3743
Molecular Formula C19H21NO4
CAS Number 465-65-6
SMILES OC1=CC=C2C[C@H]3N(CC=C)CC[C@@]45[C@@H](OC1=C24)C(=O)CC[C@@]35O
External Links
DRUGBANK DB01183
PubChem Compound 5284596
PDR 23987
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.09 - 2.09 - HANSCH,C ET AL. (1995)
Melting Point 202.5 ℃ 200-205 ℃ DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 2.0 % ~2 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 0.88 ng/ml 0.88 ng/ml IM,intramuscular injection; DRUGBANK
C Max 2.9 ng/ml 2.91 ng/ml nasal spray; DRUGBANK
C Max 4.8 ng/ml 4.83 ng/ml nasal spray; DRUGBANK
C Max 10.0 ng/ml 10±1 ng/ml adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 0.38 h 0.38 h IM,intramuscular injection; DRUGBANK
T Max 0.33 h 0.33 h nasal spray; DRUGBANK
T Max 0.50 h 0.5 h nasal spray; DRUGBANK
Clearance 1.3 L/h/kg 22.0 ml/min/kg Neonates ↑ ;RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Clearance 1.4 L/h/kg 23 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 2.1 L/kg 2.1 L/kg Neonates ↑ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.7 L/kg 1.7 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 1.2 h 1.24 h IM,intramuscular injection; DRUGBANK
Half-life 1.9 h 1.85 h nasal spray; DRUGBANK
Half-life 2.1 h 2.08 h nasal spray; DRUGBANK
Half-life 1.1 h 1.1±0.6 h Neonates → ; The Pharmacological Basis of Therapeutics
Half-life 0.0800 h 4.8(2-10) min distribution half-life; The Pharmacological Basis of Therapeutics
Half-life 1.1 h 1.1 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 150.0 mg/kg 150±5 mg/kg intravenous injection, IV; mouse; DRUGBANK
Toxicity LD50 109.0 mg/kg 109±4 mg/kg intravenous injection, IV; Rattus, Rat; DRUGBANK
Eliminate Route 0 % ~0 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 0.1 mg/kg/dose 0.1 mg/kg/dose intravenous injection, IV;IM,intramuscular injection; Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for neonates 1.0 spray/dose 1 spray/dose nasal spray Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for neonates 4.0 mg/dose 4 mg/dose nasal spray Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for infants 0.1 mg/kg/dose 0.1 mg/kg/dose intravenous injection, IV;IM,intramuscular injection;intratracheally;subcutaneous injection, SC; Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for infants 1.0 spray/dose 1 spray/dose nasal spray Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for infants 4.0 mg/dose 4 mg/dose nasal spray Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for children 2.0 mg/dose 2 mg/dose intravenous injection, IV;IM,intramuscular injection;intratracheally;subcutaneous injection, SC; Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for children 1.0 spray/dose 1 spray/dose nasal spray Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for children 4.0 mg/dose 4 mg/dose nasal spray Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for children 0.1 mg/kg/dose 0.1 mg/kg/dose intravenous injection, IV;IM,intramuscular injection;intratracheally;subcutaneous injection, SC; Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for children 1.0 spray/dose 1 spray/dose nasal spray Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for children 4.0 mg/dose 4 mg/dose nasal spray Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for adolescents 2.0 mg/dose 2 mg/dose intravenous injection, IV;IM,intramuscular injection;intratracheally;subcutaneous injection, SC; Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for adolescents 1.0 spray/dose 1 spray/dose nasal spray Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for adolescents 4.0 mg/dose 4 mg/dose nasal spray Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for adults 2.0 mg/dose 2 mg/dose intravenous injection, IV;IM,intramuscular injection;intratracheally;subcutaneous injection, SC; Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for adults 1.0 spray/dose 1 spray/dose nasal spray Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for adults 4.0 mg/dose 4 mg/dose nasal spray Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for adults 0.1 mg/kg/day 0.1 mg/kg/day Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for geriatric 2.0 mg/dose 2 mg/dose intravenous injection, IV;IM,intramuscular injection;intraosseous;subcutaneous injection, SC; Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for geriatric 1.0 spray/dose 1 spray/dose nasal spray Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for geriatric 4.0 mg/dose 4 mg/dose nasal spray Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for geriatric 0.1 mg/kg/day 0.1 mg/kg/day Naloxone Hydrochloride Injection (1 mg/mL) naloxone hydrochloride PDR
Max dose for neonates 0.1 mg/kg/dose 0.1 mg/kg/dose intravenous injection, IV;IM,intramuscular injection; Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for neonates 1.0 spray/dose 1 spray/dose nasal spray Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for neonates 4.0 mg/dose 4 mg/dose nasal spray Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for infants 0.1 mg/kg/dose 0.1 mg/kg/dose intravenous injection, IV;IM,intramuscular injection;intratracheally;subcutaneous injection, SC; Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for infants 1.0 spray/dose 1 spray/dose nasal spray Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for infants 4.0 mg/dose 4 mg/dose nasal spray Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for children 2.0 mg/dose 2 mg/dose intravenous injection, IV;IM,intramuscular injection;intratracheally;subcutaneous injection, SC; Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for children 1.0 spray/dose 1 spray/dose nasal spray Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for children 4.0 mg/dose 4 mg/dose nasal spray Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for children 0.1 mg/kg/dose 0.1 mg/kg/dose intravenous injection, IV;IM,intramuscular injection;intratracheally;subcutaneous injection, SC; Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for children 1.0 spray/dose 1 spray/dose nasal spray Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for children 4.0 mg/dose 4 mg/dose nasal spray Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for adolescents 2.0 mg/dose 2 mg/dose intravenous injection, IV;IM,intramuscular injection;intratracheally;subcutaneous injection, SC; Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for adolescents 1.0 spray/dose 1 spray/dose nasal spray Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for adolescents 4.0 mg/dose 4 mg/dose nasal spray Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for adults 2.0 mg/dose 2 mg/dose intravenous injection, IV;IM,intramuscular injection;intratracheally;subcutaneous injection, SC; Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for adults 1.0 spray/dose 1 spray/dose nasal spray Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for adults 4.0 mg/dose 4 mg/dose nasal spray Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for adults 0.1 mg/kg/day 0.1 mg/kg/day Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for geriatric 2.0 mg/dose 2 mg/dose intravenous injection, IV;IM,intramuscular injection;intratracheally;subcutaneous injection, SC; Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for geriatric 1.0 spray/dose 1 spray/dose nasal spray Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for geriatric 4.0 mg/dose 4 mg/dose nasal spray Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR
Max dose for geriatric 0.1 mg/kg/day 0.1 mg/kg/day Naloxone Hydrochloride Injection (0.4 mg/mL) naloxone hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1